| Gene Information | |
|---|---|
| Gene Name | PALM |
| Organism | Homo sapiens (Human) |
| Gene Length | 387 |
| Protein Names | Paralemmin-1 (Paralemmin) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000099864 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | O75781 |
| Gene Card | PALM |
| Uniprot ID | O75781 |
| Pfam | PF03285 |
| In ASD | no |
| Allosteric Prediction | no (-0.45031467) |
| Ortholog in Animals | Alpaca_ PALM ( ortholog_one2one ) Dog_ PALM ( ortholog_one2one ) Macaque_ PALM ( ortholog_one2one ) Mouse_ Palm ( ortholog_one2one ) Pig_ PALM ( ortholog_one2one ) Rat_ Palm ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PALM3, PALMD, PALM2AKAP2 |
| Tissue | NA |
| Tissue Specificity | Widely expressed with highest expression in brain and testis and intermediate expression in heart and adrenal gland. |
| Pharmacological Animal Models | 0.058713(Chimpanzee);0.070650(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs1050457 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:14978216}; Cytoplasmic side {ECO:0000269|PubMed:14978216}. Cell projection, filopodium membrane {ECO:0000269|PubMed:14978216}; Lipid-anchor {ECO:0000269|PubMed:14978216}. Cell projection, axon {ECO:0000250}. Cell projection, dendrite {ECO:0000250}. Cell projection, dendritic spine {ECO:0000250}. Basolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Apicolateral cell membrane {ECO:0000250}; Lipid-anchor {ECO:0000250}. Note=Translocation to the plasma membrane is enhanced upon stimulation of neuronal activity. |
| Mouse PG classification | NA |
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