| Gene Information | |
|---|---|
| Gene Name | DNASE1L3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 305 |
| Protein Names | Deoxyribonuclease gamma (DNase gamma) (EC 3.1.21.-) (DNase I homolog protein DHP2) (Deoxyribonuclease I-like 3) (DNase I-like 3) (Liver and spleen DNase) (LS-DNase) (LSD) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000163687 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13609 |
| Gene Card | DNASE1L3 |
| Uniprot ID | Q13609 |
| Pfam | PF03372 |
| In ASD | no |
| Allosteric Prediction | no (-1.190410807) |
| Ortholog in Animals | Alpaca_ DNASE1L3 ( ortholog_one2one ) Dog_ DNASE1L3 ( ortholog_one2one ) GuineaPig_ DNASE1L3 ( ortholog_one2one ) Macaque_ DNASE1L3 ( ortholog_one2one ) Mouse_ Dnase1l3 ( ortholog_one2one ) Pig_ DNASE1L3 ( ortholog_one2one ) Rat_ Dnase1l3 ( ortholog_one2one ) Rabbit_ DNASE1L3 ( ortholog_one2one ) |
| Ohnologs | DNASE1L1 |
| Paralogs | DNASE1L1, DNASE1, DNASE1L2 |
| Tissue | spleen |
| Tissue Specificity | Liver and spleen. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 7KIU (X-ray 2.22A ) |
| DBSNP | rs763778721 rs74350392 rs12491947 rs35677470 rs76440799 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11141064, ECO:0000269|PubMed:23229555}. Endoplasmic reticulum {ECO:0000269|PubMed:23229555}. Secreted {ECO:0000269|PubMed:9714828}. Note=Translocates from the endoplasmic reticulum to the nucleus during apoptosis (PubMed:23229555). Contradictory reports exist about the subcellular localization under normal physiological conditions. Under conditions of cell death, may diffuse and/or be actively transported to the nucleus. {ECO:0000269|PubMed:23229555, ECO:0000305}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |