| Gene Information | |
|---|---|
| Gene Name | PRKG1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 671 |
| Protein Names | cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000185532 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | Q13976 |
| Gene Card | PRKG1 |
| Uniprot ID | Q13976 |
| Pfam | PF00027; PF16808; PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (1.000193182) |
| Ortholog in Animals | Alpaca_ PRKG1 ( ortholog_one2one ) Dog_ PRKG1 ( ortholog_one2one ) GuineaPig_ PRKG1 ( ortholog_one2one ) Macaque_ PRKG1 ( ortholog_one2one ) Mouse_ Prkg1 ( ortholog_one2one ) Pig_ PRKG1 ( ortholog_one2one ) Rat_ AABR07006724.1 ( ortholog_one2one ) Rabbit_ PRKG1 ( ortholog_one2one ) |
| Ohnologs | PRKG2 |
| Paralogs | PRKX, PRKG2, PRKACB, PRKACG, PRKACA |
| Tissue | NA |
| Tissue Specificity | Primarily expressed in lung and placenta. {ECO:0000269|PubMed:9192852}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ZXA (NMR - ) 3NMD (X-ray 2.27A ) 3OCP (X-ray 2.49A ) 3OD0 (X-ray 2.90A ) 3OGJ (X-ray 2.75A ) 4KU7 (X-ray 1.65A ) 4KU8 (X-ray 1.99A ) 4QX5 (X-ray 1.32A ) 4QXK (Other 2.20A ) 4R4L (X-ray 2.25A ) 4R4M (X-ray 1.92A ) 4Z07 (X-ray 2.50A ) 5J48 (X-ray 1.49A ) 5JAX (X-ray 1.49A ) 5JD7 (X-ray 1.75A ) 5L0N (X-ray 1.28A ) 6BDL (X-ray 1.96A ) 6BG2 (X-ray 1.83A ) 6C0T (X-ray 1.98A ) 7LV3 (X-ray 2.41A ) 7MBJ (X-ray 1.26A ) 7SSB (X-ray 1.40A ) |
| DBSNP | rs397515330 rs56082459 rs34997494 rs149710600 rs750949508 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250}. Note=Colocalized with TRPC7 in the plasma membrane. {ECO:0000250}. |
| Mouse PG classification | NA |
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