Gene Information
Gene NamePRKAA1
OrganismHomo sapiens (Human)
Gene Length559
Protein Names5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)
Target Name5'-amp-activated protein kinase catalytic subunit alpha-1
Target TypeNA
Gene Age>4290 ( ENSG00000132356 )
Evolutionary StageEukaryota
AlphaFoldDBQ13131
Gene CardPRKAA1
Uniprot IDQ13131
PfamPF16579; PF00069
In ASDno
Allosteric Predictionyes (1.837083033)
Ortholog in AnimalsAlpaca_ PRKAA1 ( ortholog_one2one )
Dog_ PRKAA1 ( ortholog_one2one )
GuineaPig_ PRKAA1 ( ortholog_one2one )
Macaque_ PRKAA1 ( ortholog_one2one )
Mouse_ Prkaa1 ( ortholog_one2one )
Pig_ PRKAA1 ( ortholog_one2one )
Rat_ Prkaa1 ( ortholog_one2one )
Rabbit_ PRKAA1 ( ortholog_one2one )
OhnologsPRKAA2
ParalogsTSSK6, SNRK, SIK2, SIK3, NIM1K, NUAK2, TSSK2, TSSK4, SIK1, PRKAA2, BRSK2, NUAK1, BRSK1, HUNK, TSSK1B, MELK, TSSK3
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.262101(Rat);0.093455(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 4RED  (X-ray  2.95A  )  4RER  (X-ray  4.05A  )  4REW  (X-ray  4.58A  )  5EZV  (X-ray  2.99A  )  6C9F  (X-ray  2.92A  )  6C9G  (X-ray  2.70A  )  6C9H  (X-ray  2.65A  )  6C9J  (X-ray  3.05A  )  7JHG  (EM  3.47A  )  7JHH  (EM  3.92A  )  7JIJ  (X-ray  5.50A  )  7M74  (EM  3.93A  ) 
DBSNP rs17855679  rs928784854 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:15866171}. Nucleus {ECO:0000269|PubMed:15866171}. Note=In response to stress, recruited by p53/TP53 to specific promoters. {ECO:0000269|PubMed:15866171}.
Mouse PG classificationNA
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