| Gene Information | |
|---|---|
| Gene Name | PCSK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 638 |
| Protein Names | Neuroendocrine convertase 2 (NEC 2) (EC 3.4.21.94) (KEX2-like endoprotease 2) (Prohormone convertase 2) (Proprotein convertase 2) (PC2) |
| Target Name | neuroendocrine convertase 2 |
| Target Type | Literature-reported target |
| Gene Age | 810 ( ENSG00000125851 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P16519 |
| Gene Card | PCSK2 |
| Uniprot ID | P16519 |
| Pfam | PF01483; PF00082; PF16470 |
| In ASD | no |
| Allosteric Prediction | yes (0.627805814) |
| Ortholog in Animals | Alpaca_ PCSK2 ( ortholog_one2one ) Dog_ PCSK2 ( ortholog_one2one ) GuineaPig_ PCSK2 ( ortholog_one2one ) Macaque_ PCSK2 ( ortholog_one2one ) Mouse_ Pcsk2 ( ortholog_one2one ) Pig_ PCSK2 ( ortholog_one2one ) Rat_ Pcsk2 ( ortholog_one2one ) Rabbit_ PCSK2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PCSK1, TPP2, PCSK6, MBTPS1, PCSK7, PCSK5, PCSK9, PCSK4, FURIN |
| Tissue | adrenal.gland, cerebral.cortex, skin, thyroid |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);0.005990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs201718679 rs17854040 rs144151196 rs780820865 rs200711626 rs17857236 rs139619496 |
| Subcellular location [CC] | Cytoplasmic vesicle, secretory vesicle. Secreted {ECO:0000269|PubMed:28719828}. Note=Localized in the secretion granules. |
| Mouse PG classification | NA |
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