| Gene Information | |
|---|---|
| Gene Name | SPAG9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1321 |
| Protein Names | C-Jun-amino-terminal kinase-interacting protein 4 (JIP-4) (JNK-interacting protein 4) (Cancer/testis antigen 89) (CT89) (Human lung cancer oncogene 6 protein) (HLC-6) (JNK-associated leucine-zipper protein) (JLP) (Mitogen-activated protein kinase 8-interacting protein 4) (Proliferation-inducing protein 6) (Protein highly expressed in testis) (PHET) (Sperm surface protein) (Sperm-associated antigen 9) (Sperm-specific protein) (Sunday driver 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000008294 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O60271 |
| Gene Card | SPAG9 |
| Uniprot ID | O60271 |
| Pfam | PF16471; PF09744 |
| In ASD | no |
| Allosteric Prediction | no (-0.411584347) |
| Ortholog in Animals | Alpaca_ SPAG9 ( ortholog_one2one ) Dog_ SPAG9 ( ortholog_one2one ) GuineaPig_ SPAG9 ( ortholog_one2one ) Macaque_ SPAG9 ( ortholog_one2one ) Mouse_ Spag9 ( ortholog_one2one ) Pig_ SPAG9 ( ortholog_one2one ) Rat_ Spag9 ( ortholog_one2one ) Rabbit_ SPAG9 ( ortholog_one2one ) |
| Ohnologs | MAPK8IP3 |
| Paralogs | MAPK8IP3 |
| Tissue | NA |
| Tissue Specificity | Expressed only in testis on the round spermatids of stage I, II and II. Absent in spermatogonia and spermatocyte. {ECO:0000269|PubMed:9480848}.; [Isoform 4]: Expressed in testis and in acute myeloid leukemia (AML) patients. {ECO:0000269|PubMed:16112646}.; [Isoform 3]: Expressed in testis. {ECO:0000269|PubMed:14662895}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2W83 (X-ray 1.93A ) |
| DBSNP | rs9896965 |
| Subcellular location [CC] | Cytoplasm {ECO:0000250|UniProtKB:Q58A65}. Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:Q58A65}. Lysosome membrane {ECO:0000269|PubMed:29146937}. Note=Perinuclear distribution in response to stress signals such as UV radiation. {ECO:0000250|UniProtKB:Q58A65}.; [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269|PubMed:15693750}. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. {ECO:0000269|PubMed:15693750}. |
| Mouse PG classification | NA |
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