| Gene Information | |
|---|---|
| Gene Name | PRKACB |
| Organism | Homo sapiens (Human) |
| Gene Length | 351 |
| Protein Names | cAMP-dependent protein kinase catalytic subunit beta (PKA C-beta) (EC 2.7.11.11) |
| Target Name | camp-dependent protein kinase catalytic subunit beta |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000142875 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P22694 |
| Gene Card | PRKACB |
| Uniprot ID | P22694 |
| Pfam | PF00069 |
| In ASD | yes |
| Allosteric Prediction | yes (0.99994683) |
| Ortholog in Animals | Alpaca_ PRKACB ( ortholog_one2one ) Dog_ PRKACB ( ortholog_one2one ) GuineaPig_ PRKACB ( ortholog_one2one ) Macaque_ PRKACB ( ortholog_one2one ) Mouse_ Prkacb ( ortholog_one2one ) Pig_ PRKACB ( ortholog_one2one ) Rat_ Prkacb ( ortholog_one2one ) Rabbit_ PRKACB ( ortholog_one2one ) |
| Ohnologs | PRKACA, PRKACG |
| Paralogs | PRKX, PRKG2, PRKACG, PRKG1, PRKACA |
| Tissue | NA |
| Tissue Specificity | Isoform 1 is most abundant in the brain, with low level expression in kidney. Isoform 2 is predominantly expressed in thymus, spleen and kidney. Isoform 3 and isoform 4 are only expressed in the brain. {ECO:0000269|PubMed:11589697}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs768056300 rs36117118 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21423175}. Cell membrane {ECO:0000269|PubMed:21423175}. Membrane {ECO:0000305}; Lipid-anchor {ECO:0000305}. Nucleus {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. {ECO:0000250}. |
| Mouse PG classification | NA |
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