| Gene Information | |
|---|---|
| Gene Name | PRK2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 984 |
| Protein Names | Serine/threonine-protein kinase N2 (EC 2.7.11.13) (PKN gamma) (Protein kinase C-like 2) (Protein-kinase C-related kinase 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q16513 |
| Gene Card | PKN2 |
| Uniprot ID | Q16513 |
| Pfam | PF02185; PF00069; PF00433 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. Expressed in numerous tumor cell lines, especially in bladder tumor cells. {ECO:0000269|PubMed:10026169, ECO:0000269|PubMed:21754995}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4CRS (X-ray 2.75A ) 4RRV (X-ray 1.41A ) 6CCY (X-ray 2.18A ) 6GBE (NMR - ) |
| DBSNP | rs12039846 rs35207128 rs12085658 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:11356191, ECO:0000269|PubMed:17332740}. Nucleus {ECO:0000269|PubMed:11356191}. Membrane {ECO:0000250|UniProtKB:Q8BWW9}. Cell projection, lamellipodium {ECO:0000269|PubMed:11356191}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11356191}. Cleavage furrow {ECO:0000269|PubMed:17332740}. Midbody {ECO:0000269|PubMed:17332740}. Cell junction {ECO:0000269|PubMed:20974804}. Note=Colocalizes with PTPN13 in lamellipodia-like structures, regions of large actin turnover. Accumulates during telophase at the cleavage furrow and concentrates finally around the midbody in cytokinesis. Recruited to nascent cell-cell contacts at the apical surface of cells. In the course of viral infection, colocalizes with HCV NS5B at perinuclear region in the cytoplasm. {ECO:0000269|PubMed:11356191, ECO:0000269|PubMed:17332740}. |
| Mouse PG classification | NA |
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