| Gene Information | |
|---|---|
| Gene Name | PRIMPOL |
| Organism | Homo sapiens (Human) |
| Gene Length | 560 |
| Protein Names | DNA-directed primase/polymerase protein (hPrimpol1) (EC 2.7.7.-) (Coiled-coil domain-containing protein 111) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000164306 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q96LW4 |
| Gene Card | PRIMPOL |
| Uniprot ID | Q96LW4 |
| Pfam | PF01896 |
| In ASD | no |
| Allosteric Prediction | no (-1.110764015) |
| Ortholog in Animals | Alpaca_ PRIMPOL ( ortholog_one2one ) Dog_ PRIMPOL ( ortholog_one2one ) GuineaPig_ PRIMPOL ( ortholog_one2one ) Macaque_ PRIMPOL ( ortholog_one2one ) Mouse_ Primpol ( ortholog_one2one ) Pig_ PRIMPOL ( ortholog_one2one ) Rat_ Primpol ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.002990(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5L2X (X-ray 2.20A ) 5N85 (X-ray 2.00A ) 5N8A (X-ray 1.28A ) 7JK1 (X-ray 2.62A ) 7JKL (X-ray 2.38A ) 7JKP (X-ray 2.59A ) 7JL8 (X-ray 2.10A ) 7JLG (X-ray 2.07A ) |
| DBSNP | rs200857997 rs2463447 rs14969 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:24207056, ECO:0000269|PubMed:24240614}. Mitochondrion matrix {ECO:0000269|PubMed:24207056}. Chromosome {ECO:0000269|PubMed:28534480}. Note=Present in the nucleus, but a larger fraction is localized inside mitochondria (PubMed:24207056). Associates with nuclear chromatin during the G1 and S phases of unperturbed cell cycles (PubMed:24207056). Recruited to stalled replication forks following interaction with RPA1 (PubMed:28534480). {ECO:0000269|PubMed:24207056, ECO:0000269|PubMed:28534480}. |
| Mouse PG classification | HPG |
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