| Gene Information | |
|---|---|
| Gene Name | PAPPA |
| Organism | Homo sapiens (Human) |
| Gene Length | 1627 |
| Protein Names | Pappalysin-1 (EC 3.4.24.79) (Insulin-like growth factor-dependent IGF-binding protein 4 protease) (IGF-dependent IGFBP-4 protease) (IGFBP-4ase) (Pregnancy-associated plasma protein A) (PAPP-A) |
| Target Name | pappalysin-1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000182752 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q13219 |
| Gene Card | PAPPA |
| Uniprot ID | Q13219 |
| Pfam | PF05572; PF00084 |
| In ASD | no |
| Allosteric Prediction | no (-0.063191896) |
| Ortholog in Animals | Alpaca_ PAPPA ( ortholog_one2one ) Dog_ PAPPA ( ortholog_one2one ) GuineaPig_ PAPPA ( ortholog_one2one ) Macaque_ PAPPA ( ortholog_one2one ) Mouse_ Pappa ( ortholog_one2one ) Pig_ PAPPA ( ortholog_one2one ) Rat_ Pappa1 ( ortholog_one2one ) Rabbit_ PAPPA ( ortholog_one2one ) |
| Ohnologs | PAPPA2 |
| Paralogs | CR1L, SUSD3, F13B, SELP, SEZ6L2, CFHR2, CFHR1, CSMD1, APOH, SELE, SRPX, SVEP1, SEZ6, C8A, CD55, CSMD2, PAPPA2, SUSD6, C4BPA, C9, CR1, SELL, CFB, CD46, C4BPB, CR2, C7, CSMD3, CFHR3, CFH, SEZ6L, CFHR4, CFHR5, SRPX2, C8B, PRF1, SUSD4, C6, C2 |
| Tissue | placenta |
| Tissue Specificity | High levels in placenta and pregnancy serum. In placenta, expressed in X cells in septa and anchoring villi, and in syncytiotrophoblasts in the chorionic villi. Lower levels are found in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow, colon, fibroblasts and osteoblasts. {ECO:0000269|PubMed:10077652, ECO:0000269|PubMed:10491647, ECO:0000269|PubMed:7508748, ECO:0000269|PubMed:7526035}. |
| Pharmacological Animal Models | NULL(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs417012 rs445159 rs117124330 rs7020782 |
| Subcellular location [CC] | Secreted {ECO:0000269|PubMed:10077652}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |