| Gene Information | |
|---|---|
| Gene Name | PRDX3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 256 |
| Protein Names | Thioredoxin-dependent peroxide reductase, mitochondrial (EC 1.11.1.24) (Antioxidant protein 1) (AOP-1) (HBC189) (Peroxiredoxin III) (Prx-III) (Peroxiredoxin-3) (Protein MER5 homolog) (Thioredoxin-dependent peroxiredoxin 3) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 810 ( ENSG00000165672 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P30048 |
| Gene Card | PRDX3 |
| Uniprot ID | P30048 |
| Pfam | PF10417; PF00578 |
| In ASD | no |
| Allosteric Prediction | no (-0.369679996) |
| Ortholog in Animals | Alpaca_ PRDX3 ( ortholog_one2one ) Dog_ PRDX3 ( ortholog_one2many ) GuineaPig_ PRDX3 ( ortholog_one2one ) Macaque_ PRDX3 ( ortholog_one2one ) Mouse_ Prdx3 ( ortholog_one2one ) Pig_ PRDX3 ( ortholog_one2one ) Rat_ Prdx3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PRDX1, PRDX6, PRDX2, PRDX4 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5JCG (X-ray 2.80A ) 5UCX (X-ray 2.40A ) |
| DBSNP | rs34698541 rs202061531 rs140609531 rs11554902 rs548327727 rs36064375 rs35697338 |
| Subcellular location [CC] | Mitochondrion {ECO:0000269|PubMed:33889951}. Cytoplasm {ECO:0000305|PubMed:12492477}. Early endosome {ECO:0000269|PubMed:15750338}. Note=Localizes to early endosomes in a RPS6KC1-dependent manner. {ECO:0000269|PubMed:15750338}. |
| Mouse PG classification | NA |
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