| Gene Information | |
|---|---|
| Gene Name | PRG3 |
| Organism | Homo sapiens (Human) |
| Gene Length | 373 |
| Protein Names | Ferroptosis suppressor protein 1 (FSP1) (EC 1.6.5.-) (Apoptosis-inducing factor homologous mitochondrion-associated inducer of death) (AMID) (p53-responsive gene 3 protein) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 244 ( ENSG00000156575 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | Q9BRQ8 |
| Gene Card | AIFM2 |
| Uniprot ID | Q9BRQ8 |
| Pfam | PF07992 |
| In ASD | no |
| Allosteric Prediction | yes (0.12212736) |
| Ortholog in Animals | Alpaca_ PRG3 ( ortholog_one2one ) Dog_ PRG3 ( ortholog_one2one ) Macaque_ PRG3 ( ortholog_one2one ) Mouse_ Prg3 ( ortholog_one2one ) Rat_ Prg3 ( ortholog_one2one ) Rabbit_ PRG3 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PRG2 |
| Tissue | bone.marrow |
| Tissue Specificity | Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas. Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells. {ECO:0000269|PubMed:12135761}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs10999147 rs2271694 |
| Subcellular location [CC] | Lipid droplet {ECO:0000269|PubMed:31634900}. Cell membrane {ECO:0000269|PubMed:31634900}; Lipid-anchor {ECO:0000305}. Cytoplasm {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:12135761, ECO:0000269|PubMed:26689472}. Mitochondrion membrane {ECO:0000269|PubMed:11980907, ECO:0000269|PubMed:26689472}. Nucleus {ECO:0000269|PubMed:26689472}. |
| Mouse PG classification | NA |
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