| Gene Information | |
|---|---|
| Gene Name | AQP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 269 |
| Protein Names | Aquaporin-1 (AQP-1) (Aquaporin-CHIP) (Urine water channel) (Water channel protein for red blood cells and kidney proximal tubule) |
| Target Name | aquaporin-1 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000240583 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P29972 |
| Gene Card | AQP1 |
| Uniprot ID | P29972 |
| Pfam | PF00230 |
| In ASD | no |
| Allosteric Prediction | yes (0.301279684) |
| Ortholog in Animals | Alpaca_ AQP1 ( ortholog_one2one ) Dog_ AQP1 ( ortholog_one2one ) GuineaPig_ AQP1 ( ortholog_one2one ) Mouse_ Aqp1 ( ortholog_one2one ) Pig_ AQP1 ( ortholog_one2one ) Rat_ Aqp1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | MIP, AQP3, AQP5, AQP4, AQP6, AQP10, AQP8, AQP7B, AQP7, AQP9, AQP2 |
| Tissue | NA |
| Tissue Specificity | Detected in erythrocytes (at protein level). Expressed in a number of tissues including erythrocytes, renal tubules, retinal pigment epithelium, heart, lung, skeletal muscle, kidney and pancreas. Weakly expressed in brain, placenta and liver. {ECO:0000269|PubMed:23219802}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1FQY (X-ray 3.80A ) 1H6I (X-ray 3.54A ) 1IH5 (X-ray 3.70A ) 4CSK (X-ray 3.28A ) 6POJ (NMR - ) 7UZE (EM 2.40A ) 8CT2 (EM 3.10A ) 8CTE (EM 2.90A ) |
| DBSNP | rs104894004 rs28362692 rs28362731 |
| Subcellular location [CC] | Cell membrane {ECO:0000269|PubMed:23219802}; Multi-pass membrane protein {ECO:0000269|PubMed:23219802}. |
| Mouse PG classification | NA |
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