Gene Information
Gene NameGRHL2
OrganismHomo sapiens (Human)
Gene Length625
Protein NamesGrainyhead-like protein 2 homolog (Brother of mammalian grainyhead) (Transcription factor CP2-like 3)
Target NameNA
Target TypeNA
Gene Age987 ( ENSG00000083307 )
Evolutionary StageOpisthokonta
AlphaFoldDBQ6ISB3
Gene CardGRHL2
Uniprot IDQ6ISB3
PfamPF04516
In ASDno
Allosteric Predictionno (-0.915284655)
Ortholog in AnimalsAlpaca_ GRHL2 ( ortholog_one2one )
Dog_ GRHL2 ( ortholog_one2one )
GuineaPig_ GRHL2 ( ortholog_one2one )
Macaque_ GRHL2 ( ortholog_one2one )
Mouse_ Grhl2 ( ortholog_one2one )
Pig_ GRHL2 ( ortholog_one2one )
Rat_ Grhl2 ( ortholog_one2one )
Rabbit_ GRHL2 ( ortholog_one2one )
OhnologsGRHL1, GRHL3
ParalogsGRHL1, GRHL3, TFCP2L1, UBP1, TFCP2
Tissueepididymis, heart, placenta, prostate, seminal.vesicle, tongue, vas.deferens, zone.of.skin
Tissue SpecificityExpressed in keratinocytes (at protein level). Highly expressed in placenta, prostate, brain and kidney. Lower-level expression in a variety of epithelial tissues such as thymus, lung, salivary gland, mammary gland and digestive tract. Expressed in the cochlear. Expressed in corneal epithelial cells, but not in the endothelium or stroma (PubMed:29499165). {ECO:0000269|PubMed:12175488, ECO:0000269|PubMed:12393799, ECO:0000269|PubMed:20978075, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29499165}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 5MR7  (X-ray  2.50A  ) 
DBSNP rs587777737  rs3779617  rs587777738 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:20938050, ECO:0000269|PubMed:25152456, ECO:0000269|PubMed:29499165}. Membrane {ECO:0000269|PubMed:25152456}. Note=detected at cell-cell contact areas. {ECO:0000269|PubMed:25152456}.
Mouse PG classificationLPG
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