| Gene Information | |
|---|---|
| Gene Name | RIPOR2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1068 |
| Protein Names | Rho family-interacting cell polarization regulator 2 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 886 ( ENSG00000111913 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q9Y4F9 |
| Gene Card | RIPOR2 |
| Uniprot ID | Q9Y4F9 |
| Pfam | PF15903 |
| In ASD | no |
| Allosteric Prediction | no (-0.96466006) |
| Ortholog in Animals | Alpaca_ RIPOR2 ( ortholog_one2one ) Dog_ RIPOR2 ( ortholog_one2one ) GuineaPig_ RIPOR2 ( ortholog_one2one ) Macaque_ RIPOR2 ( ortholog_one2one ) Mouse_ Ripor2 ( ortholog_one2one ) Pig_ RIPOR2 ( ortholog_one2one ) Rat_ Ripor2 ( ortholog_one2one ) Rabbit_ RIPOR2 ( ortholog_one2one ) |
| Ohnologs | RIPOR1, RIPOR3 |
| Paralogs | RIPOR3, RIPOR1 |
| Tissue | whole.blood |
| Tissue Specificity | Expressed in primary fetal mononuclear myoblast (PubMed:17150207). Expressed strongly in naive T lymphocytes (PubMed:27556504). Expressed weakly in activated T lymphocytes (at protein level) (PubMed:27556504). Expressed in blood cells and adult tissues of hematopoietic origin, such as the secondary lymphoid organs (PubMed:23241886). Expressed in cytotrophoblast (PubMed:9055809). {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886, ECO:0000269|PubMed:27556504, ECO:0000269|PubMed:9055809}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11967003 rs35331811 rs34016544 rs34298086 rs35514577 rs35780910 rs760676508 rs9461073 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:17150207, ECO:0000269|PubMed:23241886}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:17150207}. Cell projection, filopodium {ECO:0000269|PubMed:17150207}. Cell projection, stereocilium {ECO:0000250|UniProtKB:Q80U16}. Cell projection, stereocilium membrane {ECO:0000250|UniProtKB:Q7TP54}. Apical cell membrane {ECO:0000250|UniProtKB:Q7TP54}. Note=Localized in the cytoplasm in cells undergoing mitosis (PubMed:17150207). Colocalized with F-actin (PubMed:17150207). Localized with RHOC within the basal domain of hair cell stereocilia, near the taper region (By similarity). Detected in punctate pattern forming a circumferential ring at the stereocilia base (By similarity). Localized to the apical stereocilia of inner and outer hair cells (By similarity). Not detected as a membrane-associated protein in stereocilia (By similarity). {ECO:0000250|UniProtKB:Q7TP54, ECO:0000250|UniProtKB:Q80U16, ECO:0000269|PubMed:17150207}.; [Isoform 1]: Cytoplasm {ECO:0000269|PubMed:24687993}.; [Isoform 2]: Cytoplasm {ECO:0000269|PubMed:25588844}. Note=Accumulates at the leading edge of polarized neutrophils in a chemokine-dependent manner (PubMed:25588844). {ECO:0000269|PubMed:25588844}. |
| Mouse PG classification | NA |
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