| Gene Information | |
|---|---|
| Gene Name | PREB |
| Organism | Homo sapiens (Human) |
| Gene Length | 417 |
| Protein Names | Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1292 ( ENSG00000138073 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9HCU5 |
| Gene Card | PREB |
| Uniprot ID | Q9HCU5 |
| Pfam | PF00400 |
| In ASD | no |
| Allosteric Prediction | no (-0.337170308) |
| Ortholog in Animals | Alpaca_ PREB ( ortholog_one2one ) Dog_ PREB ( ortholog_one2one ) GuineaPig_ PREB ( ortholog_one2one ) Macaque_ PREB ( ortholog_one2one ) Mouse_ Preb ( ortholog_one2one ) Pig_ PREB ( ortholog_one2one ) Rat_ Preb ( ortholog_one2one ) Rabbit_ PREB ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:10920239, ECO:0000269|PubMed:12735795}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 5TF2 (X-ray 2.80A ) |
| DBSNP | NA |
| Subcellular location [CC] | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9WTV0}; Single-pass membrane protein {ECO:0000250|UniProtKB:Q9WTV0}. Nucleus {ECO:0000250|UniProtKB:Q9WTV0}. Note=Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). {ECO:0000269|PubMed:25202031, ECO:0000269|PubMed:28442536}. |
| Mouse PG classification | NA |
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