| Gene Information | |
|---|---|
| Gene Name | PRDM9 |
| Organism | Homo sapiens (Human) |
| Gene Length | 894 |
| Protein Names | Histone-lysine N-methyltransferase PRDM9 (PR domain zinc finger protein 9) (PR domain-containing protein 9) (Protein-lysine N-methyltransferase PRDM9) (EC 2.1.1.-) ([histone H3]-lysine36 N-trimethyltransferase PRDM9) (EC 2.1.1.359) ([histone H3]-lysine4 N-trimethyltransferase PRDM9) (EC 2.1.1.354) ([histone H3]-lysine9 N-trimethyltransferase PRDM9) (EC 2.1.1.355) ([histone H4]-N-methyl-L-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.362) ([histone H4]-lysine20 N-methyltransferase PRDM9) (EC 2.1.1.361) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 25 ( ENSG00000164256 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q9NQV7 |
| Gene Card | PRDM9 |
| Uniprot ID | Q9NQV7 |
| Pfam | PF01352; PF00856; PF09514; PF00096 |
| In ASD | no |
| Allosteric Prediction | yes (0.010069643) |
| Ortholog in Animals | Alpaca_ PRDM9 ( ortholog_one2one ) Mouse_ Zfp78 ( ortholog_many2many ) |
| Ohnologs | ZNF23, ZNF791, ZNF594, ZNF267, ZNF699, ZNF700, ZNF433, ZNF197 |
| Paralogs | ZNF875, ZNF556, ZNF248, ZFP90, ZFP69, ZNF891, ZNF20, ZNF487, ZNF778, ZNF614, ZNF491, ZNF440, ZNF69, ZNF763, ZNF439, ZNF582, ZNF684, ZNF35, ZNF558, ZNF557, ZNF619, ZNF596, ZNF343, ZFP37, ZNF180, ZNF80, ZNF749, ZNF550, ZNF124, ZNF169, ZNF404, ZNF329, ZNF133, ZNF554, ZNF705A, ZNF705D, ZNF705B, ZNF705G, ZNF19, ZNF560, ZNF264, ZNF599, ZNF805, ZNF589, ZNF555, ZNF266, ZNF566, ZNF620, ZNF425, ZNF337, ZFP69B, ZNF10, ZNF177, ZNF77, ZNF674, KRBOX4, ZNF669, ZNF846, ZNF529, ZNF25, ZNF70, ZNF559 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 4IJD (X-ray 2.15A ) 5EGB (X-ray 1.98A ) 5EH2 (X-ray 2.05A ) 5EI9 (X-ray 1.92A ) 6NM4 (X-ray 2.58A ) |
| DBSNP | rs6875787 rs146505774 rs77287813 rs61051796 |
| Subcellular location [CC] | Nucleus {ECO:0000250|UniProtKB:Q96EQ9}. Chromosome {ECO:0000250|UniProtKB:Q96EQ9}. Note=Localizes in nuclei of pre-leptotene, leptotene, and early to mid-zygotene spermatocytes. {ECO:0000250|UniProtKB:Q96EQ9}. |
| Mouse PG classification | NA |
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