Gene Information
Gene NamePRDM2
OrganismHomo sapiens (Human)
Gene Length1718
Protein NamesPR domain zinc finger protein 2 (EC 2.1.1.355) (GATA-3-binding protein G3B) (Lysine N-methyltransferase 8) (MTB-ZF) (MTE-binding protein) (PR domain-containing protein 2) (Retinoblastoma protein-interacting zinc finger protein) (Zinc finger protein RIZ)
Target NameNA
Target TypeNA
Gene Age544 ( ENSG00000116731 )
Evolutionary StageEumetazoa
AlphaFoldDBQ13029
Gene CardPRDM2
Uniprot IDQ13029
PfamPF00856; PF00096
In ASDno
Allosteric Predictionno (-0.382470741)
Ortholog in AnimalsAlpaca_ PRDM2 ( ortholog_one2one )
Dog_ PRDM2 ( ortholog_one2one )
GuineaPig_ PRDM2 ( ortholog_one2one )
Macaque_ PRDM2 ( ortholog_one2one )
Mouse_ Prdm2 ( ortholog_one2one )
Pig_ PRDM2 ( ortholog_one2one )
Rat_ Prdm2 ( ortholog_one2one )
Rabbit_ PRDM2 ( ortholog_one2one )
OhnologsNA
ParalogsZBTB17, ZNF527, ZNF467, ZNF530, ZNF784, ZNF416, ZNF746, ZNF547, ZKSCAN7, ZNF407, ZNF646, ZNF852, ZNF408, ZNF774, ZNF572, ZNF426, ZNF398, ZNF333, ZNF223, ZNF222, ZNF287, ZNF625, ZNF644, ZNF233, PRDM4, ZNF697, ZNF319, ZNF34, ZNF285, WIZ, ZNF507, ZNF136, ZNF592, GZF1, ZBTB41, ZNF214, ZNF777, ZNF417, ZNF587, ZFP57, ZNF776, ZNF687, MYNN, ZNF627, ZNF707, ZNF17, ZNF670, ZNF230, ZNF155, ZNF768
TissueNA
Tissue SpecificityHighly expressed in retinoblastoma cell lines and in brain tumors. Also expressed in a number of other cell lines and in brain, heart, skeletal muscle, liver and spleen. Isoform 1 is expressed in testis at much higher level than isoform 3. {ECO:0000269|PubMed:8654390, ECO:0000269|PubMed:9006946}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 2JV0  (NMR  -  )  2QPW  (X-ray  1.79A  ) 
DBSNP rs2076324  rs17350795 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:14633678, ECO:0000269|PubMed:7538672, ECO:0000269|PubMed:9006946}.
Mouse PG classificationNA
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