| Gene Information | |
|---|---|
| Gene Name | PLPPR4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 763 |
| Protein Names | Phospholipid phosphatase-related protein type 4 (Brain-specific phosphatidic acid phosphatase-like protein 1) (Inactive 2-lysophosphatidate phosphatase PLPPR4) (Lipid phosphate phosphatase-related protein type 4) (Plasticity-related gene 1 protein) (PRG-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 987 ( ENSG00000117600 ) |
| Evolutionary Stage | Opisthokonta |
| AlphaFoldDB | Q7Z2D5 |
| Gene Card | PLPPR4 |
| Uniprot ID | Q7Z2D5 |
| Pfam | PF01569 |
| In ASD | no |
| Allosteric Prediction | no (-1.077617281) |
| Ortholog in Animals | Alpaca_ PLPPR4 ( ortholog_one2one ) Dog_ PLPPR4 ( ortholog_one2one ) GuineaPig_ PLPPR4 ( ortholog_one2one ) Macaque_ PLPPR4 ( ortholog_one2one ) Mouse_ Plppr4 ( ortholog_one2one ) Pig_ PLPPR4 ( ortholog_one2one ) Rat_ Plppr4 ( ortholog_one2one ) Rabbit_ PLPPR4 ( ortholog_one2one ) |
| Ohnologs | PLPPR2, PLPPR3, PLPPR1 |
| Paralogs | PLPPR5, PLPPR1, PLPP3, PLPP4, PLPP2, PLPPR3, PLPPR2, PLPP1, PLPP5 |
| Tissue | brain, cerebral.cortex, amygdala, caudate.nucleus, hippocampus, hypothalamus, nucleus.accumbens, pituitary.gland, putamen, substantia.nigra |
| Tissue Specificity | Expressed by glutamatergic neurons (at protein level). {ECO:0000269|PubMed:26671989}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs712896 rs35285687 rs138327459 |
| Subcellular location [CC] | Postsynaptic density membrane {ECO:0000269|PubMed:26671989}; Multi-pass membrane protein {ECO:0000255}. |
| Mouse PG classification | NA |
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