| Gene Information | |
|---|---|
| Gene Name | CDC34 |
| Organism | Homo sapiens (Human) |
| Gene Length | 236 |
| Protein Names | Ubiquitin-conjugating enzyme E2 R1 (EC 2.3.2.23) ((E3-independent) E2 ubiquitin-conjugating enzyme R1) (EC 2.3.2.24) (E2 ubiquitin-conjugating enzyme R1) (Ubiquitin-conjugating enzyme E2-32 kDa complementing) (Ubiquitin-conjugating enzyme E2-CDC34) (Ubiquitin-protein ligase R1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 382 ( ENSG00000099804 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P49427 |
| Gene Card | CDC34 |
| Uniprot ID | P49427 |
| Pfam | PF00179 |
| In ASD | yes |
| Allosteric Prediction | yes (0.08611651) |
| Ortholog in Animals | Alpaca_ CDC34 ( ortholog_one2one ) GuineaPig_ CDC34 ( ortholog_one2one ) Macaque_ CDC34 ( ortholog_one2one ) Mouse_ Cdc34 ( ortholog_one2one ) Pig_ CDC34 ( ortholog_one2one ) Rat_ Cdc34 ( ortholog_one2one ) Rabbit_ CDC34 ( ortholog_one2one ) |
| Ohnologs | UBE2R2 |
| Paralogs | UBE2T, UBE2B, UBE2O, UBE2J2, UBE2A, UBE2C, UBE2H, UBE2V1, UBE2K, UBE2W, UBE2Z, UBE2F, UBE2G2, UBE2I, UBE2V2, UBE2N, UBE2NL, PEDS1, UBE2U, UBE2J1, UBE2G1, UBE2S, UBE2R2, AKTIP |
| Tissue | testis |
| Tissue Specificity | Expressed in testes during spermatogenesis to regulate repression of cAMP-induced transcription. {ECO:0000269|PubMed:10373550}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.046154(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2OB4 (X-ray 2.40A ) 3RZ3 (X-ray 2.30A ) 4MDK (X-ray 2.61A ) 7M2K (X-ray 2.47A ) |
| DBSNP | rs16990650 |
| Subcellular location [CC] | Cytoplasm. Nucleus. Note=The phosphorylation of the C-terminal tail plays an important role in mediating nuclear localization. Colocalizes with beta-tubulin on mitotic spindles in anaphase. |
| Mouse PG classification | NA |
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