| Gene Information | |
|---|---|
| Gene Name | DIAPH2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1101 |
| Protein Names | Protein diaphanous homolog 2 (Diaphanous-related formin-2) (DRF2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1064 ( ENSG00000147202 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | O60879 |
| Gene Card | DIAPH2 |
| Uniprot ID | O60879 |
| Pfam | PF06367; PF06371; PF02181 |
| In ASD | no |
| Allosteric Prediction | no (-1.226327274) |
| Ortholog in Animals | Alpaca_ DIAPH2 ( ortholog_one2one ) Macaque_ DIAPH2 ( ortholog_one2one ) Mouse_ Diaph2 ( ortholog_one2one ) Pig_ DIAPH2 ( ortholog_one2one ) Rat_ AABR07040412.1 ( ortholog_one2one ) Rabbit_ DIAPH2 ( ortholog_one2one ) |
| Ohnologs | DIAPH1, DIAPH3 |
| Paralogs | FHOD3, FHOD1, FHDC1, GRID2IP, FAM47B, DAAM2, FNBP4, SHTN1, FAM47C, FAM47A, FMNL1, DAAM1, DIAPH3, FMN2, FMNL3, FMNL2, INF2, DIAPH1 |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs20361 rs20361 |
| Subcellular location [CC] | [Isoform 3]: Cytoplasm, cytosol. Early endosome. Note=Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes. |
| Mouse PG classification | NA |
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