| Gene Information | |
|---|---|
| Gene Name | PPT1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 306 |
| Protein Names | Palmitoyl-protein thioesterase 1 (PPT-1) (EC 3.1.2.22) (Palmitoyl-protein hydrolase 1) |
| Target Name | palmitoyl-protein thioesterase 1 |
| Target Type | Clinical trial target |
| Gene Age | 1488 ( ENSG00000131238 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P50897 |
| Gene Card | PPT1 |
| Uniprot ID | P50897 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (1.02017483) |
| Ortholog in Animals | Alpaca_ PPT1 ( ortholog_one2one ) Dog_ PPT1 ( ortholog_one2one ) GuineaPig_ PPT1 ( ortholog_one2one ) Macaque_ PPT1 ( ortholog_one2one ) Mouse_ Ppt1 ( ortholog_one2one ) Pig_ PPT1 ( ortholog_one2one ) Rat_ Ppt1 ( ortholog_one2one ) Rabbit_ PPT1 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PPT2, DOLPP1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3GRO (X-ray 2.53A ) |
| DBSNP | rs386833626 rs386833627 rs386833631 rs137852702 rs137852696 rs137852697 rs137852701 rs386833642 rs137852695 rs1800205 rs386833646 rs386833647 rs386833650 rs148412181 rs148412181 rs386833657 rs386833658 rs137852698 rs386833661 rs386833663 rs386833665 rs386833666 rs386833669 rs386833671 |
| Subcellular location [CC] | Lysosome {ECO:0000269|PubMed:19941651}. Secreted {ECO:0000250|UniProtKB:P45478}. |
| Mouse PG classification | NA |
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