| Gene Information | |
|---|---|
| Gene Name | DPEP1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 411 |
| Protein Names | Dipeptidase 1 (EC 3.4.13.19) (Beta-lactamase) (EC 3.5.2.6) (Dehydropeptidase-I) (Microsomal dipeptidase) (Renal dipeptidase) (hRDP) |
| Target Name | dehydropeptidase i |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000015413 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | P16444 |
| Gene Card | DPEP1 |
| Uniprot ID | P16444 |
| Pfam | PF01244 |
| In ASD | no |
| Allosteric Prediction | yes (0.41832413) |
| Ortholog in Animals | Alpaca_ DPEP1 ( ortholog_one2one ) Dog_ DPEP1 ( ortholog_one2one ) GuineaPig_ DPEP1 ( ortholog_one2one ) Macaque_ DPEP1 ( ortholog_one2one ) Mouse_ Dpep1 ( ortholog_one2one ) Pig_ DPEP1 ( ortholog_one2one ) Rat_ Dpep1 ( ortholog_one2one ) Rabbit_ DPEP1 ( ortholog_one2one ) |
| Ohnologs | DPEP3, DPEP2 |
| Paralogs | DPEP2, DPEP3 |
| Tissue | kidney, pancreas, small.intestine, small.intestine.Peyers.patch |
| Tissue Specificity | Expressed in lung and kidneys. {ECO:0000269|PubMed:31442408, ECO:0000269|PubMed:8439558}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1ITQ (X-ray 2.30A ) 1ITU (X-ray 2.00A ) |
| DBSNP | rs1043397364 rs1126464 rs1126464 |
| Subcellular location [CC] | Apical cell membrane {ECO:0000269|PubMed:28413640}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}. Cell projection, microvillus membrane {ECO:0000269|PubMed:2168407}; Lipid-anchor, GPI-anchor {ECO:0000269|PubMed:2168407}. Note=Brush border membrane. {ECO:0000250|UniProtKB:P31429}. |
| Mouse PG classification | NA |
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