Gene Information
Gene NamePPP5C
OrganismHomo sapiens (Human)
Gene Length499
Protein NamesSerine/threonine-protein phosphatase 5 (PP5) (EC 3.1.3.16) (Protein phosphatase T) (PP-T) (PPT)
Target Nameserine/threonine-protein phosphatase 5
Target TypeNA
Gene Age>4290 ( ENSG00000011485 )
Evolutionary StageEukaryota
AlphaFoldDBP53041
Gene CardPPP5C
Uniprot IDP53041
PfamPF00149; PF08321; PF00515
In ASDno
Allosteric Predictionyes (1.40700043)
Ortholog in AnimalsAlpaca_ PPP5C ( ortholog_one2one )
Dog_ PPP5C ( ortholog_one2one )
GuineaPig_ PPP5C ( ortholog_one2one )
Macaque_ PPP5C ( ortholog_one2one )
Mouse_ Ppp5c ( ortholog_one2one )
Pig_ PPP5C ( ortholog_one2one )
Rat_ Ppp5c ( ortholog_one2one )
Rabbit_ PPP5C ( ortholog_one2one )
OhnologsNA
ParalogsPPP3CC, PPP3CB, PPP6C, PPP2CB, PPP2CA, PPEF2, PPP4C, PPP3CA, PPEF1, PPP1CA, PPP1CC, PPP1CB
TissueNA
Tissue SpecificityUbiquitous. {ECO:0000269|PubMed:15546861}.
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1A17  (X-ray  2.45A  )  1S95  (X-ray  1.60A  )  1WAO  (X-ray  2.90A  )  2BUG  (NMR  -  )  3H60  (X-ray  2.00A  )  3H61  (X-ray  1.45A  )  3H62  (X-ray  1.40A  )  3H63  (X-ray  1.30A  )  3H64  (X-ray  1.90A  )  3H66  (X-ray  2.59A  )  3H67  (X-ray  1.65A  )  3H68  (X-ray  1.50A  )  3H69  (X-ray  2.10A  )  4ZVZ  (X-ray  2.00A  )  4ZX2  (X-ray  1.23A  )  5HPE  (X-ray  2.27A  )  5UI1  (X-ray  1.96A  )  5WG8  (X-ray  1.65A  ) 
DBSNP NA 
Subcellular location [CC]Nucleus {ECO:0000269|PubMed:15383005}. Cytoplasm {ECO:0000269|PubMed:15383005, ECO:0000269|PubMed:19948726}. Cell membrane {ECO:0000269|PubMed:19948726}. Note=Predominantly nuclear (PubMed:15383005). But also present in the cytoplasm (PubMed:15383005). Translocates from the cytoplasm to the plasma membrane in a RAC1-dependent manner (PubMed:19948726). {ECO:0000269|PubMed:15383005, ECO:0000269|PubMed:19948726}.
Mouse PG classificationNA
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