| Gene Information | |
|---|---|
| Gene Name | DOK7 |
| Organism | Homo sapiens (Human) |
| Gene Length | 504 |
| Protein Names | Protein Dok-7 (Downstream of tyrosine kinase 7) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 1714 ( ENSG00000175920 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q18PE1 |
| Gene Card | DOK7 |
| Uniprot ID | Q18PE1 |
| Pfam | PF02174 |
| In ASD | no |
| Allosteric Prediction | no (-0.257075253) |
| Ortholog in Animals | Alpaca_ DOK7 ( ortholog_one2one ) Dog_ HGFAC ( ortholog_one2one ) GuineaPig_ DOK7 ( ortholog_one2one ) Macaque_ DOK7 ( ortholog_one2one ) Mouse_ Dok7 ( ortholog_one2one ) Rat_ Dok7 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | heart, atrium, cerebellar.hemisphere, cerebellum, left.ventricle, pituitary.gland, skeletal.muscle |
| Tissue Specificity | Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen (at protein level). {ECO:0000269|PubMed:16794080}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.010990(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | rs763233743 rs62272670 rs940346413 rs138010842 rs1429428597 rs571769859 rs770987150 rs754633490 rs758131044 rs781227659 rs1286619522 rs768892432 rs118203994 rs16844422 rs16844460 rs115614731 rs6811423 rs150728781 rs6831659 rs560463670 rs370039804 rs16844464 rs2020433 rs753026831 rs16844470 rs9684786 rs147185207 rs184556570 |
| Subcellular location [CC] | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Synapse {ECO:0000250}. Note=Accumulates at neuromuscular junctions. {ECO:0000250}. |
| Mouse PG classification | NA |
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