| Gene Information | |
|---|---|
| Gene Name | PPP2R2B |
| Organism | Homo sapiens (Human) |
| Gene Length | 443 |
| Protein Names | Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000156475 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q00005 |
| Gene Card | PPP2R2B |
| Uniprot ID | Q00005 |
| Pfam | NA |
| In ASD | no |
| Allosteric Prediction | yes (0.64774386) |
| Ortholog in Animals | Alpaca_ PPP2R2B ( ortholog_one2one ) Dog_ PPP2R2B ( ortholog_one2one ) GuineaPig_ PPP2R2B ( ortholog_one2one ) Macaque_ PPP2R2B ( ortholog_one2one ) Mouse_ Ppp2r2b ( ortholog_one2one ) Pig_ PPP2R2B ( ortholog_one2one ) Rat_ Ppp2r2b ( ortholog_one2one ) Rabbit_ PPP2R2B ( ortholog_one2one ) |
| Ohnologs | PPP2R2D, PPP2R2A, PPP2R2C |
| Paralogs | PPP2R2D, PPP2R2A, PPP2R2C |
| Tissue | cerebral.cortex |
| Tissue Specificity | Brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs11547494 |
| Subcellular location [CC] | [Isoform 1]: Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Membrane {ECO:0000250}.; [Isoform 2]: Cytoplasm {ECO:0000250}. Mitochondrion {ECO:0000250}. Mitochondrion outer membrane {ECO:0000250}. Note=Under basal conditions, localizes to both cytosolic and mitochondrial compartments. Relocalizes from the cytosolic to the mitochondrial compartment during apoptosis. Its targeting to the outer mitochondrial membrane (OMM) involves an association with import receptors of the TOM complex and is required to promote proapoptotic activity (By similarity). {ECO:0000250}. |
| Mouse PG classification | LPG |
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