| Gene Information | |
|---|---|
| Gene Name | NOX1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 564 |
| Protein Names | NADPH oxidase 1 (NOX-1) (EC 1.-.-.-) (Mitogenic oxidase 1) (MOX-1) (NADH/NADPH mitogenic oxidase subunit P65-MOX) (NOH-1) |
| Target Name | nadph oxidase 1 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000007952 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9Y5S8 |
| Gene Card | NOX1 |
| Uniprot ID | Q9Y5S8 |
| Pfam | PF08022; PF01794; PF08030 |
| In ASD | no |
| Allosteric Prediction | yes (1.166766824) |
| Ortholog in Animals | Alpaca_ NOX1 ( ortholog_one2one ) Dog_ NOX1 ( ortholog_one2one ) GuineaPig_ NOX1 ( ortholog_one2one ) Macaque_ NOX1 ( ortholog_one2one ) Mouse_ Nox1 ( ortholog_one2one ) Pig_ NOX1 ( ortholog_one2one ) Rat_ Nox1 ( ortholog_one2one ) Rabbit_ NOX1 ( ortholog_one2one ) |
| Ohnologs | CYBB, NOX3, NOX4 |
| Paralogs | NOX3, DUOX1, NOX5, NOX4, DUOX2, CYBB |
| Tissue | colon, rectum, transverse.colon |
| Tissue Specificity | NOH-1L is detected in colon, uterus, prostate, and colon carcinoma, but not in peripheral blood leukocytes. NOH-1S is detected only in colon and colon carcinoma cells. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | rs2071756 rs34688635 rs35404864 |
| Subcellular location [CC] | Cell projection, invadopodium membrane {ECO:0000269|PubMed:19755710}; Multi-pass membrane protein {ECO:0000269|PubMed:19755710}. Cell membrane {ECO:0000269|PubMed:26301257}. |
| Mouse PG classification | NA |
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