| Gene Information | |
|---|---|
| Gene Name | KCNJ2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 427 |
| Protein Names | Inward rectifier potassium channel 2 (Cardiac inward rectifier potassium channel) (Inward rectifier K(+) channel Kir2.1) (IRK-1) (hIRK1) (Potassium channel, inwardly rectifying subfamily J member 2) |
| Target Name | inward rectifier potassium channel 2 |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000123700 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | P63252 |
| Gene Card | KCNJ2 |
| Uniprot ID | P63252 |
| Pfam | PF01007; PF17655; PF08466 |
| In ASD | yes |
| Allosteric Prediction | yes (0.999754414) |
| Ortholog in Animals | Alpaca_ KCNJ2 ( ortholog_one2one ) Dog_ KCNJ2 ( ortholog_one2one ) GuineaPig_ KCNJ2 ( ortholog_one2one ) Macaque_ KCNJ2 ( ortholog_one2one ) Mouse_ Kcnj2 ( ortholog_one2one ) Pig_ KCNJ2 ( ortholog_one2one ) Rat_ Kcnj2 ( ortholog_one2one ) Rabbit_ KCNJ2 ( ortholog_one2one ) |
| Ohnologs | KCNJ4, KCNJ14, KCNJ12, KCNJ3 |
| Paralogs | KCNJ9, KCNJ3, KCNJ5, KCNJ6, KCNJ11, KCNJ15, KCNJ10, KCNJ13, KCNJ8, KCNJ1, KCNJ14, KCNJ18, KCNJ4, KCNJ12, KCNJ16 |
| Tissue | NA |
| Tissue Specificity | Heart, brain, placenta, lung, skeletal muscle, and kidney. Diffusely distributed throughout the brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.2(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 6SPZ (X-ray 2.08A ) |
| DBSNP | rs199473650 rs104894580 rs104894575 rs104894585 rs147750704 rs104894584 rs104894581 rs104894583 rs104894578 rs104894579 rs104894582 rs199473387 |
| Subcellular location [CC] | Membrane; Multi-pass membrane protein. Membrane; Lipid-anchor {ECO:0000269|PubMed:25043870}. |
| Mouse PG classification | HPG |
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