Gene Information
Gene NamePPP1CC
OrganismHomo sapiens (Human)
Gene Length323
Protein NamesSerine/threonine-protein phosphatase PP1-gamma catalytic subunit (PP-1G) (EC 3.1.3.16) (Protein phosphatase 1C catalytic subunit)
Target Nameserine/threonine-protein phosphatase pp1-gamma catalytic subunit
Target TypeNA
Gene Age645 ( ENSG00000186298 )
Evolutionary StageEukaryota
AlphaFoldDBP36873
Gene CardPPP1CC
Uniprot IDP36873
PfamPF00149; PF16891
In ASDno
Allosteric Predictionyes (0.973051799)
Ortholog in AnimalsAlpaca_ PPP1CC ( ortholog_one2one )
Dog_ PPP1CC ( ortholog_one2one )
GuineaPig_ PPP1CC ( ortholog_one2one )
Mouse_ Ppp1cc ( ortholog_one2one )
Pig_ PPP1CC ( ortholog_one2one )
Rat_ Ppp1cc ( ortholog_one2one )
Rabbit_ PPP1CC ( ortholog_one2one )
OhnologsPPP1CA
ParalogsPPP1CA, PPP3CC, PPP3CB, PPP6C, PPP5C, PPP2CB, PPP2CA, PPEF2, PPP4C, PPP3CA, PPEF1, PPP1CB
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNULL(Chimpanzee);NULL(Mouse);0.011342(Rat);0.088763(Rabbit)
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1IT6  (X-ray  2.00A  )  1JK7  (X-ray  1.90A  )  1U32  (X-ray  2.00A  )  2BCD  (X-ray  2.10A  )  2BDX  (X-ray  2.30A  )  4UT2  (X-ray  1.96A  )  4UT3  (X-ray  2.19A  )  5INB  (X-ray  1.30A  )  5J28  (X-ray  2.00A  )  7SD0  (EM  2.95A  ) 
DBSNP rs11558237 
Subcellular location [CC]Cytoplasm {ECO:0000269|PubMed:11739654}. Nucleus. Nucleus, nucleolus {ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:20926688, ECO:0000269|PubMed:23789093}. Nucleus, nucleoplasm {ECO:0000269|PubMed:11739654}. Nucleus speckle {ECO:0000269|PubMed:11739654}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12529430}. Cleavage furrow {ECO:0000269|PubMed:12529430}. Midbody {ECO:0000269|PubMed:12529430}. Mitochondrion {ECO:0000269|PubMed:17936702}. Cytoplasm, cytoskeleton, microtubule organizing center {ECO:0000269|PubMed:23789093}. Note=Colocalizes with SPZ1 in the nucleus (By similarity). Colocalizes with URI1 at mitochondrion (PubMed:17936702). Rapidly exchanges between the nucleolar, nucleoplasmic and cytoplasmic compartments (PubMed:11739654). Highly mobile in cells and can be relocalized through interaction with targeting subunits (PubMed:17965019). In the presence of PPP1R8 relocalizes from the nucleolus to nuclear speckles (PubMed:11739654). Shows a dynamic targeting to specific sites throughout the cell cycle (PubMed:12529430). Highly concentrated in nucleoli of interphase cells and localizes at kinetochores early in mitosis (PubMed:12529430). Relocalization to chromosome-containing regions occurs at the transition from early to late anaphase (PubMed:12529430). Also accumulates at the cleavage furrow and midbody by telophase (PubMed:12529430). Colocalizes with DYNLT4 in the microtubule organizing center (MTOC)(PubMed:23789093). {ECO:0000250|UniProtKB:P63087, ECO:0000269|PubMed:11739654, ECO:0000269|PubMed:12529430, ECO:0000269|PubMed:17936702, ECO:0000269|PubMed:17965019, ECO:0000269|PubMed:23789093}.
Mouse PG classificationNA
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