| Gene Information | |
|---|---|
| Gene Name | PPOX |
| Organism | Homo sapiens (Human) |
| Gene Length | 131 |
| Protein Names | Hypocretin neuropeptide precursor (Hypocretin) (Hcrt) (Orexin precursor) (Prepro-orexin) (Preprohypocretin) [Cleaved into: Orexin-A (Hypocretin-1) (Hcrt1); Orexin-B (Hypocretin-2) (Hcrt2)] |
| Target Name | protoporphyrinogen oxidase |
| Target Type | Successful target |
| Gene Age | 1488 ( ENSG00000143224 ) |
| Evolutionary Stage | Euk+Bac |
| AlphaFoldDB | O43612 |
| Gene Card | HCRT |
| Uniprot ID | O43612 |
| Pfam | PF02072 |
| In ASD | no |
| Allosteric Prediction | yes (0.353771709) |
| Ortholog in Animals | Alpaca_ PPOX ( ortholog_one2one ) Dog_ PPOX ( ortholog_one2one ) GuineaPig_ PPOX ( ortholog_one2one ) Macaque_ PPOX ( ortholog_one2one ) Mouse_ Ppox ( ortholog_one2one ) Pig_ PPOX ( ortholog_one2one ) Rat_ Ppox ( ortholog_one2one ) Rabbit_ PPOX ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | KDM1A, MAOA, SMOX, KDM1B, PAOX, MAOB, IL4I1 |
| Tissue | NA |
| Tissue Specificity | Abundantly expressed in subthalamic nucleus but undetectable in other brain regions tested (hypothalamus was not tested) and in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. {ECO:0000269|PubMed:9491897}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1CQ0 (NMR - ) 1R02 (NMR - ) 1UVQ (X-ray 1.80A ) 1WSO (NMR - ) 7L1U (EM 3.20A ) |
| DBSNP | rs104894574 |
| Subcellular location [CC] | Rough endoplasmic reticulum {ECO:0000250|UniProtKB:O55232}. Cytoplasmic vesicle {ECO:0000250|UniProtKB:O55232}. Synapse {ECO:0000250|UniProtKB:O55232}. Note=Associated with perikaryal rough endoplasmic reticulum as well as cytoplasmic large granular vesicles at synapses. {ECO:0000250|UniProtKB:O55232}. |
| Mouse PG classification | LPG |
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