| Gene Information | |
|---|---|
| Gene Name | KCNQ4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 695 |
| Protein Names | Potassium voltage-gated channel subfamily KQT member 4 (KQT-like 4) (Potassium channel subunit alpha KvLQT4) (Voltage-gated potassium channel subunit Kv7.4) |
| Target Name | potassium voltage-gated channel subfamily kqt member 4 |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000117013 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | P56696 |
| Gene Card | KCNQ4 |
| Uniprot ID | P56696 |
| Pfam | PF00520; PF03520 |
| In ASD | no |
| Allosteric Prediction | yes (0.379371651) |
| Ortholog in Animals | Alpaca_ KCNQ4 ( ortholog_one2one ) Dog_ KCNQ4 ( ortholog_one2one ) GuineaPig_ KCNQ4 ( ortholog_one2one ) Macaque_ KCNQ4 ( ortholog_one2one ) Mouse_ Kcnq4 ( ortholog_one2one ) Pig_ KCNQ4 ( ortholog_one2one ) Rat_ Kcnq4 ( ortholog_one2one ) Rabbit_ KCNQ4 ( ortholog_one2one ) |
| Ohnologs | KCNQ2, KCNQ3, KCNQ5 |
| Paralogs | KCNS1, KCND1, KCNA7, KCNB2, KCNG3, KCNQ1, KCNQ3, KCNC4, KCNV1, KCNA1, KCNA10, KCNC3, KCNV2, KCND3, KCNQ2, KCNB1, KCNA6, KCNA2, KCNA5, KCNG1, KCND2, KCNC1, KCNC2, KCNA4, KCNA3, KCNQ5, KCNF1, KCNG2, KCNG4, KCNS3, KCNS2 |
| Tissue | NA |
| Tissue Specificity | Expressed in the outer, but not the inner, sensory hair cells of the cochlea. Slightly expressed in heart, brain and skeletal muscle. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 2OVC (X-ray 2.07A ) 4GOW (X-ray 2.60A ) 6N5W (X-ray 2.15A ) 7BYL (EM 2.50A ) 7BYM (EM 3.10A ) 7BYN (EM 3.30A ) 7VNP (EM 2.79A ) 7VNQ (EM 2.96A ) 7VNR (EM 2.80A ) |
| DBSNP | rs80358276 rs80358277 rs80358278 rs28937588 rs28937588 rs137853969 rs28939710 rs34287852 |
| Subcellular location [CC] | Basal cell membrane; Multi-pass membrane protein. Note=Situated at the basal membrane of cochlear outer hair cells. {ECO:0000250}. |
| Mouse PG classification | HPG |
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