| Gene Information | |
|---|---|
| Gene Name | UBQLN2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 624 |
| Protein Names | Ubiquilin-2 (Chap1) (DSK2 homolog) (Protein linking IAP with cytoskeleton 2) (PLIC-2) (hPLIC-2) (Ubiquitin-like product Chap1/Dsk2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 132 ( ENSG00000188021 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9UHD9 |
| Gene Card | UBQLN2 |
| Uniprot ID | Q9UHD9 |
| Pfam | PF00627; PF00240 |
| In ASD | no |
| Allosteric Prediction | yes (0.215606603) |
| Ortholog in Animals | Alpaca_ UBQLN2 ( ortholog_one2one ) GuineaPig_ UBQLN2 ( ortholog_one2one ) Macaque_ UBQLN2 ( ortholog_one2one ) Mouse_ Ubqln2 ( ortholog_one2one ) Pig_ UBQLN2 ( ortholog_one2one ) Rat_ Ubqln2 ( ortholog_one2one ) Rabbit_ UBQLN2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | UBQLN1, UBL7, UBQLN4, UBQLN3, UBQLNL |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);0.016854(Mouse);0.001375(Rat);0.014286(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1J8C (NMR - ) 2NBV (NMR - ) 6MUN (NMR - ) 7F7X (NMR - ) |
| DBSNP | rs374522677 rs1490021329 rs17002693 rs1001930696 rs749463696 rs1243726473 rs1569254459 rs387906709 rs387906710 rs387906711 rs387906712 rs369947678 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:18199683}. Nucleus {ECO:0000269|PubMed:9853615}. Membrane {ECO:0000250|UniProtKB:Q9QZM0}. Cytoplasmic vesicle, autophagosome {ECO:0000269|PubMed:19148225}. Note=Colocalizes with a subset of proteasomes, namely those that are cytoskeleton associated or free in the cytosol. Associated with fibers in mitotic cells. {ECO:0000269|PubMed:10983987}. |
| Mouse PG classification | NA |
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