| Gene Information | |
|---|---|
| Gene Name | PPM1E |
| Organism | Homo sapiens (Human) |
| Gene Length | 755 |
| Protein Names | Protein phosphatase 1E (EC 3.1.3.16) (Ca(2+)/calmodulin-dependent protein kinase phosphatase N) (CaMKP-N) (CaMKP-nucleus) (CaMKN) (Partner of PIX 1) (Partner of PIX-alpha) (Partner of PIXA) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000175175 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q8WY54 |
| Gene Card | PPM1E |
| Uniprot ID | Q8WY54 |
| Pfam | PF00481 |
| In ASD | no |
| Allosteric Prediction | no (-0.606972456) |
| Ortholog in Animals | Alpaca_ PPM1E ( ortholog_one2one ) Dog_ PPM1E ( ortholog_one2one ) GuineaPig_ PPM1E ( ortholog_one2one ) Macaque_ PPM1E ( ortholog_one2one ) Mouse_ Ppm1e ( ortholog_one2one ) Pig_ PPM1E ( ortholog_one2one ) Rat_ Ppm1e ( ortholog_one2one ) Rabbit_ PPM1E ( ortholog_one2one ) |
| Ohnologs | PPM1F |
| Paralogs | PDP2, TAB1, ILKAP, PPM1B, PPM1L, PPM1N, PP2D1, PDP1, PPM1A, PPM1D, PPM1G, PPM1H, PPM1J, PPM1M, PPM1F, PPM1K |
| Tissue | adrenal.gland, brain, testis, cerebral.cortex |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.04(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:15496589, ECO:0000269|PubMed:16269004}. Cytoplasm {ECO:0000269|PubMed:15496589, ECO:0000269|PubMed:16269004}. Note=A truncated form, major form, with the C-terminal part missing, is mostly found in the cytoplasm and a little in the nucleus. The full-length, minor form, is found in the nucleus. {ECO:0000269|PubMed:15496589, ECO:0000269|PubMed:16269004}. |
| Mouse PG classification | NA |
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