| Gene Information | |
|---|---|
| Gene Name | PPM1A |
| Organism | Homo sapiens (Human) |
| Gene Length | 382 |
| Protein Names | Protein phosphatase 1A (EC 3.1.3.16) (Protein phosphatase 2C isoform alpha) (PP2C-alpha) (Protein phosphatase IA) |
| Target Name | protein phosphatase 1a |
| Target Type | Clinical trial target |
| Gene Age | >4290 ( ENSG00000100614 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P35813 |
| Gene Card | PPM1A |
| Uniprot ID | P35813 |
| Pfam | PF00481; PF07830 |
| In ASD | no |
| Allosteric Prediction | no (-0.064559784) |
| Ortholog in Animals | Alpaca_ PPM1A ( ortholog_one2one ) Dog_ PPM1A ( ortholog_one2one ) GuineaPig_ PPM1A ( ortholog_one2one ) Macaque_ PPM1A ( ortholog_one2one ) Mouse_ Ppm1a ( ortholog_one2one ) Pig_ PPM1A ( ortholog_one2one ) Rat_ Ppm1a ( ortholog_one2one ) Rabbit_ PPM1A ( ortholog_one2one ) |
| Ohnologs | PPM1B |
| Paralogs | PDP2, TAB1, ILKAP, PPM1B, PPM1L, PPM1N, PP2D1, PDP1, PPM1D, PPM1E, PPM1G, PPM1H, PPM1J, PPM1M, PPM1F, PPM1K |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.000730(Chimpanzee);0.001000(Mouse);NULL(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1A6Q (X-ray 2.00A ) 3FXJ (X-ray 2.50A ) 3FXK (X-ray 2.10A ) 3FXL (X-ray 2.30A ) 3FXM (X-ray 2.50A ) 3FXO (X-ray 2.50A ) 4RA2 (X-ray 1.94A ) 4RAF (X-ray 2.00A ) 4RAG (X-ray 1.85A ) 6B67 (X-ray 2.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:16751101}. Cytoplasm, cytosol {ECO:0000269|PubMed:22781750}. Membrane {ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805}; Lipid-anchor {ECO:0000269|PubMed:20213681, ECO:0000269|PubMed:25255805}. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization. {ECO:0000250|UniProtKB:P49443}. |
| Mouse PG classification | NA |
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