| Gene Information | |
|---|---|
| Gene Name | PPLC |
| Organism | Homo sapiens (Human) |
| Gene Length | 2302 |
| Protein Names | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC 3.1.4.11) (Pancreas-enriched phospholipase C) (Phosphoinositide phospholipase C-epsilon-1) (Phospholipase C-epsilon-1) (PLC-epsilon-1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | Q9P212 |
| Gene Card | PLCE1 |
| Uniprot ID | Q9P212 |
| Pfam | PF00168; PF09279; PF00388; PF00387; PF00788; PF00617 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Widely expressed. Expressed in podocytes (PubMed:29058690). {ECO:0000269|PubMed:15558028, ECO:0000269|PubMed:29058690}.; [Isoform 1]: Broadly expressed and only absent in peripheral blood leukocytes. {ECO:0000269|PubMed:11022048, ECO:0000269|PubMed:15558028}.; [Isoform 2]: Specifically expressed in placenta, lung and spleen. {ECO:0000269|PubMed:11022047, ECO:0000269|PubMed:15558028}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 2BYE (NMR - ) 2BYF (NMR - ) 2C5L (X-ray 1.90A ) |
| DBSNP | rs17508082 rs17417407 rs121912605 rs2274224 rs3765524 rs2274223 |
| Subcellular location [CC] | Cytoplasm, cytosol. Cell membrane. Golgi apparatus membrane. Cell projection, lamellipodium {ECO:0000269|PubMed:29058690}. Note=Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Isoform 1 and isoform 2 associates with Golgi membranes. |
| Mouse PG classification | NA |
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