| Gene Information | |
|---|---|
| Gene Name | MTHFD2L |
| Organism | Homo sapiens (Human) |
| Gene Length | 347 |
| Protein Names | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein) (MTHFD2-like) [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase (EC 1.5.1.15) (EC 1.5.1.5); Methenyltetrahydrofolate cyclohydrolase (EC 3.5.4.9)] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000163738 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q9H903 |
| Gene Card | MTHFD2L |
| Uniprot ID | Q9H903 |
| Pfam | PF00763; PF02882 |
| In ASD | no |
| Allosteric Prediction | no (-0.543254902) |
| Ortholog in Animals | Alpaca_ MTHFD2L ( ortholog_one2one ) Dog_ MTHFD2L ( ortholog_one2one ) Macaque_ MTHFD2L ( ortholog_one2one ) Mouse_ Mthfd2l ( ortholog_one2one ) Pig_ MTHFD2L ( ortholog_one2one ) Rat_ Mthfd2l ( ortholog_one2one ) Rabbit_ MTHFD2L ( ortholog_one2one ) |
| Ohnologs | MTHFD2 |
| Paralogs | MTHFD1L, MTHFD1, MTHFD2 |
| Tissue | NA |
| Tissue Specificity | Isoform 1, isoform 4 and isoform 5 are expressed in brain and placenta. {ECO:0000269|PubMed:21163947}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Mitochondrion inner membrane {ECO:0000250|UniProtKB:D3ZUA0}; Peripheral membrane protein {ECO:0000250|UniProtKB:D3ZUA0}; Matrix side {ECO:0000250|UniProtKB:D3ZUA0}. |
| Mouse PG classification | NA |
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