| Gene Information | |
|---|---|
| Gene Name | UPF3B |
| Organism | Homo sapiens (Human) |
| Gene Length | 483 |
| Protein Names | Regulator of nonsense transcripts 3B (Nonsense mRNA reducing factor 3B) (Up-frameshift suppressor 3 homolog B) (hUpf3B) (Up-frameshift suppressor 3 homolog on chromosome X) (hUpf3p-X) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000125351 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | Q9BZI7 |
| Gene Card | UPF3B |
| Uniprot ID | Q9BZI7 |
| Pfam | PF03467 |
| In ASD | no |
| Allosteric Prediction | no (-0.999975623) |
| Ortholog in Animals | Alpaca_ UPF3B ( ortholog_one2one ) Macaque_ UPF3B ( ortholog_one2one ) Mouse_ Upf3b ( ortholog_one2one ) Pig_ UPF3B ( ortholog_one2one ) Rat_ Upf3b ( ortholog_one2one ) Rabbit_ UPF3B ( ortholog_one2one ) |
| Ohnologs | UPF3A |
| Paralogs | UPF3A |
| Tissue | NA |
| Tissue Specificity | Expressed in testis, uterus, prostate, heart, muscle, brain, spinal cord and placenta. {ECO:0000269|PubMed:11113196}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);NULL(Rat);0.066667(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1UW4 (X-ray 1.95A ) 2XB2 (X-ray 3.40A ) 7NWU (X-ray 2.60A ) |
| DBSNP | rs122468182 |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:11113196, ECO:0000269|PubMed:11163187}. Cytoplasm {ECO:0000269|PubMed:11163187}. Note=Shuttling between the nucleus and the cytoplasm. {ECO:0000269|PubMed:11163187}. |
| Mouse PG classification | NA |
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