| Gene Information | |
|---|---|
| Gene Name | ICH1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 452 |
| Protein Names | Caspase-2 (CASP-2) (EC 3.4.22.55) (Neural precursor cell expressed developmentally down-regulated protein 2) (NEDD-2) (Protease ICH-1) [Cleaved into: Caspase-2 subunit p18; Caspase-2 subunit p13; Caspase-2 subunit p12] |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P42575 |
| Gene Card | CASP2 |
| Uniprot ID | P42575 |
| Pfam | PF00619 |
| In ASD | yes |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | Expressed at higher levels in the embryonic lung, liver and kidney than in the heart and brain. In adults, higher level expression is seen in the placenta, lung, kidney, and pancreas than in the heart, brain, liver and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001899(Rat);0.036364(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1PYO (X-ray 1.65A ) 2P2C (X-ray 3.24A ) 3R5J (X-ray 1.77A ) 3R6G (X-ray 2.07A ) 3R6L (X-ray 1.90A ) 3R7B (X-ray 1.80A ) 3R7N (X-ray 2.33A ) 3R7S (X-ray 2.25A ) 3RJM (X-ray 2.55A ) 6GKF (X-ray 2.60A ) 6GKG (X-ray 2.85A ) 6S9K (X-ray 1.60A ) 6SAD (X-ray 2.75A ) 6Y8B (X-ray 1.54A ) 6Y8D (X-ray 1.51A ) |
| DBSNP | rs762263774 rs4647297 rs4647298 rs4647338 |
| Subcellular location [CC] | NA |
| Mouse PG classification | NA |
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