| Gene Information | |
|---|---|
| Gene Name | PPIB |
| Organism | Homo sapiens (Human) |
| Gene Length | 216 |
| Protein Names | Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (CYP-S1) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) |
| Target Name | rotamase b |
| Target Type | Successful target |
| Gene Age | 645 ( ENSG00000166794 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P23284 |
| Gene Card | PPIB |
| Uniprot ID | P23284 |
| Pfam | PF00160 |
| In ASD | no |
| Allosteric Prediction | no (-0.367179379) |
| Ortholog in Animals | Alpaca_ PPIB ( ortholog_one2one ) Dog_ PPIB ( ortholog_one2many ) GuineaPig_ PPIB ( ortholog_one2one ) Macaque_ PPIB ( ortholog_one2one ) Mouse_ Ppib ( ortholog_one2one ) Pig_ PPIB ( ortholog_one2one ) Rat_ Ppib ( ortholog_one2one ) Rabbit_ PPIB ( ortholog_one2one ) |
| Ohnologs | PPIC |
| Paralogs | PPIH, PPIL4, PPIL6, CWC27, NKTR, PPIAL4A, PPIAL4E, PPIAL4F, PPIAL4D, PPIAL4G, PPIAL4C, PPIAL4H, PPIA, PPIC, PPIE, PPIG, PPID, PPWD1, PPIF, PPIL2, PPIL3, PPIL1 |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001680(Rat);0.033333(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
|
| PDB | 1CYN (X-ray 1.85A ) 3ICH (X-ray 1.20A ) 3ICI (X-ray 1.70A ) |
| DBSNP | rs137853864 rs11558595 |
| Subcellular location [CC] | Virion {ECO:0000269|PubMed:20147391}. Note=(Microbial infection).; Endoplasmic reticulum lumen {ECO:0000269|PubMed:1530944}. Melanosome {ECO:0000269|PubMed:17081065}. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV (PubMed:17081065). {ECO:0000269|PubMed:17081065}. |
| Mouse PG classification | NA |
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