| Gene Information | |
|---|---|
| Gene Name | PPFIA2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 1257 |
| Protein Names | Liprin-alpha-2 (Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-2) (PTPRF-interacting protein alpha-2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 645 ( ENSG00000139220 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | O75334 |
| Gene Card | PPFIA2 |
| Uniprot ID | O75334 |
| Pfam | PF00536; PF07647 |
| In ASD | no |
| Allosteric Prediction | no (-0.40637025) |
| Ortholog in Animals | Alpaca_ PPFIA2 ( ortholog_one2one ) Dog_ PPFIA2 ( ortholog_one2one ) GuineaPig_ PPFIA2 ( ortholog_one2one ) Macaque_ PPFIA2 ( ortholog_one2one ) Mouse_ Ppfia2 ( ortholog_one2one ) Pig_ PPFIA2 ( ortholog_one2one ) Rat_ Ppfia2 ( ortholog_one2one ) Rabbit_ PPFIA2 ( ortholog_one2one ) |
| Ohnologs | PPFIA3, PPFIA1, PPFIA4 |
| Paralogs | PPFIBP1, PPFIBP2, PPFIA4, PPFIA1, PPFIA3 |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Expressed only in brain. {ECO:0000269|PubMed:9624153}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3TAC (X-ray 2.20A ) 3TAD (X-ray 2.90A ) 6IUH (X-ray 1.80A ) 7D2E (X-ray 1.70A ) 7D2G (X-ray 1.70A ) 7D2H (X-ray 2.20A ) |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:9624153}. Cell surface {ECO:0000269|PubMed:9624153}. Cell projection, dendritic spine {ECO:0000269|PubMed:30021165}. Note=Colocalizes with PTPRF at the cell surface. |
| Mouse PG classification | NA |
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