| Gene Information | |
|---|---|
| Gene Name | PPBP |
| Organism | Homo sapiens (Human) |
| Gene Length | 128 |
| Protein Names | Platelet basic protein (PBP) (C-X-C motif chemokine 7) (Leukocyte-derived growth factor) (LDGF) (Macrophage-derived growth factor) (MDGF) (Small-inducible cytokine B7) [Cleaved into: Connective tissue-activating peptide III (CTAP-III) (LA-PF4) (Low-affinity platelet factor IV); TC-2; Connective tissue-activating peptide III(1-81) (CTAP-III(1-81)); Beta-thromboglobulin (Beta-TG); Neutrophil-activating peptide 2(74) (NAP-2(74)); Neutrophil-activating peptide 2(73) (NAP-2(73)); Neutrophil-activating peptide 2 (NAP-2); TC-1; Neutrophil-activating peptide 2(1-66) (NAP-2(1-66)); Neutrophil-activating peptide 2(1-63) (NAP-2(1-63))] |
| Target Name | platelet basic protein |
| Target Type | NA |
| Gene Age | 332 ( ENSG00000163736 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | P02775 |
| Gene Card | PPBP |
| Uniprot ID | P02775 |
| Pfam | PF00048 |
| In ASD | no |
| Allosteric Prediction | yes (0.726927056) |
| Ortholog in Animals | Alpaca_ PPBP ( ortholog_one2one ) Dog_ PPBP ( ortholog_one2one ) Macaque_ PPBP ( ortholog_one2one ) Mouse_ Ppbp ( ortholog_one2one ) Pig_ PPBP ( ortholog_one2one ) Rat_ Ppbp ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | CXCL8, CXCL5, CXCL2, CXCL3, CXCL10, CXCL9, CXCL1, CXCL13, CXCL11, CXCL6, PF4, PF4V1 |
| Tissue | bone.marrow, spleen, lung, whole.blood |
| Tissue Specificity | NA |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1F9P (X-ray 1.93A ) 1NAP (X-ray 1.90A ) 1TVX (X-ray 1.75A ) |
| DBSNP | NA |
| Subcellular location [CC] | Secreted. |
| Mouse PG classification | NA |
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