Gene Information

Gene Information
Gene Name	PPARG
Organism	Homo sapiens (Human)
Gene Length	505
Protein Names	Peroxisome proliferator-activated receptor gamma (PPAR-gamma) (Nuclear receptor subfamily 1 group C member 3)
Target Name	peroxisome proliferator-activated receptor gamma
Target Type	Successful target
Gene Age	810 ( ENSG00000132170 )
Evolutionary Stage	Eumetazoa
AlphaFoldDB	P37231
Gene Card	PPARG
Uniprot ID	P37231
Pfam	PF00104; PF12577; PF00105
In ASD	yes
Allosteric Prediction	yes (1.448422336)
Ortholog in Animals	Alpaca_ PPARG ( ortholog_one2one ) Dog_ PPARG ( ortholog_one2one ) GuineaPig_ PPARG ( ortholog_one2one ) Macaque_ PPARG ( ortholog_one2one ) Mouse_ Pparg ( ortholog_one2one ) Pig_ PPARG ( ortholog_one2one ) Rat_ Pparg ( ortholog_one2one ) Rabbit_ PPARG ( ortholog_one2one )
Ohnologs	PPARD, RARA, RARG, PPARA
Paralogs	NR1H4, VDR, RARG, NR1D2, RARA, PPARD, NR1H2, RORC, THRB, NR1D1, NR1H3, NR1I2, NR1I3, RARB, RORB, PPARA, RORA, THRA
Tissue	NA
Tissue Specificity	Highest expression in adipose tissue. Lower in skeletal muscle, spleen, heart and liver. Also detectable in placenta, lung and ovary. {ECO:0000269\|PubMed:9065481}.
Pharmacological Animal Models	NULL(Chimpanzee);NULL(Mouse);0.316801(Rat);NULL(Rabbit)
Gene Ontology (biological process)
Gene Ontology (cellular component)
Gene Ontology (molecular function)
PDB	1FM6 (X-ray 2.10A ) 1FM9 (X-ray 2.10A ) 1I7I (X-ray 2.35A ) 1K74 (X-ray 2.30A ) 1KNU (X-ray 2.50A ) 1NYX (X-ray 2.65A ) 1PRG (X-ray 2.20A ) 1RDT (X-ray 2.40A ) 1WM0 (X-ray 2.90A ) 1ZEO (X-ray 2.50A ) 1ZGY (X-ray 1.80A ) 2ATH (X-ray 2.28A ) 2F4B (X-ray 2.07A ) 2FVJ (X-ray 1.99A ) 2G0G (X-ray 2.54A ) 2G0H (X-ray 2.30A ) 2GTK (X-ray 2.10A ) 2HFP (X-ray 2.00A ) 2HWQ (X-ray 1.97A ) 2HWR (X-ray 2.34A ) 2I4J (X-ray 2.10A ) 2I4P (X-ray 2.10A ) 2I4Z (X-ray 2.25A ) 2OM9 (X-ray 2.80A ) 2P4Y (X-ray 2.25A ) 2POB (X-ray 2.30A ) 2PRG (X-ray 2.30A ) 2Q59 (X-ray 2.20A ) 2Q5P (X-ray 2.30A ) 2Q5S (X-ray 2.05A ) 2Q61 (X-ray 2.20A ) 2Q6R (X-ray 2.41A ) 2Q6S (X-ray 2.40A ) 2Q8S (X-ray 2.30A ) 2QMV (NMR - ) 2VSR (X-ray 2.05A ) 2VST (X-ray 2.35A ) 2VV0 (X-ray 2.55A ) 2VV1 (X-ray 2.20A ) 2VV2 (X-ray 2.75A ) 2VV3 (X-ray 2.85A ) 2VV4 (X-ray 2.35A ) 2XKW (X-ray 2.02A ) 2YFE (X-ray 2.00A ) 2ZK0 (X-ray 2.36A ) 2ZK1 (X-ray 2.61A ) 2ZK2 (X-ray 2.26A ) 2ZK3 (X-ray 2.58A ) 2ZK4 (X-ray 2.57A ) 2ZK5 (X-ray 2.45A ) 2ZK6 (X-ray 2.41A ) 2ZNO (X-ray 2.40A ) 2ZVT (X-ray 1.90A ) 3ADS (X-ray 2.25A ) 3ADT (X-ray 2.70A ) 3ADU (X-ray 2.77A ) 3ADV (X-ray 2.27A ) 3ADW (X-ray 2.07A ) 3ADX (X-ray 1.95A ) 3AN3 (X-ray 2.30A ) 3AN4 (X-ray 2.30A ) 3B0Q (X-ray 2.10A ) 3B0R (X-ray 2.15A ) 3B1M (X-ray 1.60A ) 3B3K (X-ray 2.60A ) 3BC5 (X-ray 2.27A ) 3CDP (X-ray 2.80A ) 3CDS (X-ray 2.65A ) 3CS8 (X-ray 2.30A ) 3CWD (X-ray 2.40A ) 3D6D (X-ray 2.40A ) 3DZU (X-ray 3.20A ) 3DZY (X-ray 3.10A ) 3E00 (X-ray 3.10A ) 3ET0 (X-ray 2.40A ) 3ET3 (X-ray 1.95A ) 3FEJ (X-ray 2.01A ) 3FUR (X-ray 2.30A ) 3G9E (X-ray 2.30A ) 3GBK (X-ray 2.30A ) 3H0A (X-ray 2.10A ) 3HO0 (X-ray 2.60A ) 3HOD (X-ray 2.10A ) 3IA6 (X-ray 2.31A ) 3K8S (X-ray 2.55A ) 3KMG (X-ray 2.10A ) 3LMP (X-ray 1.90A ) 3NOA (X-ray 1.98A ) 3OSI (X-ray 2.70A ) 3OSW (X-ray 2.55A ) 3PBA (X-ray 2.30A ) 3PO9 (X-ray 2.35A ) 3PRG (X-ray 2.90A ) 3QT0 (X-ray 2.50A ) 3R5N (X-ray 2.00A ) 3R8A (X-ray 2.41A ) 3R8I (X-ray 2.30A ) 3S9S (X-ray 2.55A ) 3SZ1 (X-ray 2.30A ) 3T03 (X-ray 2.10A ) 3TY0 (X-ray 2.00A ) 3U9Q (X-ray 1.52A ) 3V9T (X-ray 1.65A ) 3V9V (X-ray 1.60A ) 3V9Y (X-ray 2.10A ) 3VJH (X-ray 2.22A ) 3VJI (X-ray 2.61A ) 3VN2 (X-ray 2.18A ) 3VSO (X-ray 2.00A ) 3VSP (X-ray 2.40A ) 3WJ4 (X-ray 1.95A ) 3WJ5 (X-ray 1.89A ) 3WMH (X-ray 2.10A ) 3X1H (X-ray 2.30A ) 3X1I (X-ray 2.40A ) 4A4V (X-ray 2.00A ) 4A4W (X-ray 2.00A ) 4CI5 (X-ray 1.77A ) 4E4K (X-ray 2.50A ) 4E4Q (X-ray 2.50A ) 4EM9 (X-ray 2.10A ) 4EMA (X-ray 2.54A ) 4F9M (X-ray 1.90A ) 4FGY (X-ray 2.84A ) 4HEE (X-ray 2.50A ) 4JAZ (X-ray 2.85A ) 4JL4 (X-ray 2.50A ) 4L96 (X-ray 2.38A ) 4L98 (X-ray 2.28A ) 4O8F (X-ray 2.60A ) 4OJ4 (X-ray 2.30A ) 4PRG (X-ray 2.90A ) 4PVU (X-ray 2.60A ) 4PWL (X-ray 2.60A ) 4R06 (X-ray 2.22A ) 4R2U (X-ray 2.30A ) 4R6S (X-ray 2.30A ) 4XLD (X-ray 2.45A ) 4XTA (X-ray 2.50A ) 4XUH (X-ray 2.22A ) 4XUM (X-ray 2.40A ) 4Y29 (X-ray 1.98A ) 4YT1 (X-ray 2.20A ) 5AZV (X-ray 2.70A ) 5DSH (X-ray 2.95A ) 5DV3 (X-ray 2.75A ) 5DV6 (X-ray 2.80A ) 5DV8 (X-ray 2.75A ) 5DVC (X-ray 2.30A ) 5DWL (X-ray 2.20A ) 5F9B (X-ray 2.25A ) 5GTN (X-ray 1.85A ) 5GTO (X-ray 2.10A ) 5GTP (X-ray 2.35A ) 5HZC (X-ray 2.00A ) 5JI0 (X-ray 1.98A ) 5LSG (X-ray 2.00A ) 5TTO (X-ray 2.25A ) 5TWO (X-ray 1.93A ) 5U5L (X-ray 2.55A ) 5UGM (X-ray 2.10A ) 5WQX (X-ray 2.29A ) 5WR0 (X-ray 2.85A ) 5WR1 (X-ray 2.34A ) 5Y2O (X-ray 1.80A ) 5Y2T (X-ray 1.70A ) 5YCN (X-ray 2.15A ) 5YCP (X-ray 2.00A ) 5Z5S (X-ray 1.80A ) 5Z6S (X-ray 1.80A ) 6AD9 (X-ray 2.20A ) 6AN1 (X-ray 2.69A ) 6AUG (X-ray 2.73A ) 6AVI (X-ray 2.29A ) 6C1I (X-ray 2.26A ) 6C5Q (X-ray 2.40A ) 6C5T (X-ray 2.75A ) 6D3E (X-ray 2.40A ) 6D8X (X-ray 1.90A ) 6D94 (X-ray 1.90A ) 6DBH (X-ray 2.60A ) 6DCU (X-ray 2.95A ) 6DGL (X-ray 1.95A ) 6DGO (X-ray 3.10A ) 6DGP (X-ray 3.10A ) 6DGQ (X-ray 2.45A ) 6DGR (X-ray 2.15A ) 6DH9 (X-ray 2.70A ) 6DHA (X-ray 1.88A ) 6E5A (X-ray 2.40A ) 6ENQ (X-ray 2.20A ) 6F2L (X-ray 2.10A ) 6FZF (X-ray 1.95A ) 6FZG (X-ray 2.10A ) 6FZJ (X-ray 2.01A ) 6FZP (X-ray 2.30A ) 6FZY (X-ray 3.10A ) 6ICJ (X-ray 2.48A ) 6IJR (X-ray 2.85A ) 6IJS (X-ray 2.15A ) 6ILQ (X-ray 2.41A ) 6IZM (X-ray 1.80A ) 6IZN (X-ray 1.75A ) 6JEY (X-ray 2.20A ) 6JF0 (X-ray 3.40A ) 6JQ7 (X-ray 2.55A ) 6K0T (X-ray 1.84A ) 6KTM (X-ray 2.70A ) 6KTN (X-ray 2.75A ) 6L89 (X-ray 2.10A ) 6L8B (X-ray 2.10A ) 6MCZ (X-ray 2.10A ) 6MD0 (X-ray 1.95A ) 6MD1 (X-ray 2.20A ) 6MD2 (X-ray 2.20A ) 6MD4 (X-ray 2.24A ) 6MS7 (X-ray 1.43A ) 6O67 (X-ray 2.52A ) 6O68 (X-ray 2.78A ) 6ONI (X-ray 1.80A ) 6ONJ (X-ray 2.30A ) 6PDZ (X-ray 2.10A ) 6QJ5 (X-ray 2.00A ) 6T1S (X-ray 1.65A ) 6T1V (X-ray 2.21A ) 6T6B (X-ray 2.80A ) 6T9C (X-ray 1.95A ) 6TDC (X-ray 2.33A ) 6TSG (X-ray 2.98A ) 6VZL (X-ray 2.07A ) 6VZM (X-ray 2.40A ) 6VZN (X-ray 2.30A ) 6VZO (X-ray 2.27A ) 6Y3U (X-ray 2.62A ) 6ZLY (X-ray 1.79A ) 7A7H (X-ray 2.40A ) 7AHJ (X-ray 2.10A ) 7AWC (X-ray 1.74A ) 7AWD (X-ray 1.93A ) 7CXE (X-ray 2.50A ) 7CXF (X-ray 2.35A ) 7CXG (X-ray 1.88A ) 7CXH (X-ray 2.30A ) 7CXI (X-ray 2.30A ) 7CXJ (X-ray 2.65A ) 7CXK (X-ray 2.20A ) 7CXL (X-ray 2.70A ) 7E0A (X-ray 1.77A ) 7E2O (X-ray 3.20A ) 7EFQ (X-ray 2.30A ) 7JQG (X-ray 2.15A ) 7LOT (X-ray 2.29A ) 7P4E (X-ray 2.40A ) 7QB1 (X-ray 2.20A ) 7RLE (X-ray 2.50A ) 7WOX (X-ray 3.20A ) 8DKN (X-ray 1.95A ) 8DKV (X-ray 1.59A ) 8DSY (X-ray 2.95A ) 8DSZ (X-ray 2.50A )
DBSNP	rs1801282 rs1805192 rs1800571 rs121909242 rs28936407 rs72551362 rs72551363 rs72551364 rs121909244
Subcellular location [CC]	Nucleus. Cytoplasm. Note=Redistributed from the nucleus to the cytosol through a MAP2K1/MEK1-dependent manner. NOCT enhances its nuclear translocation.
Mouse PG classification	HPG
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