| Gene Information | |
|---|---|
| Gene Name | PPARD |
| Organism | Homo sapiens (Human) |
| Gene Length | 441 |
| Protein Names | Peroxisome proliferator-activated receptor delta (PPAR-delta) (NUCI) (Nuclear hormone receptor 1) (NUC1) (Nuclear receptor subfamily 1 group C member 2) (Peroxisome proliferator-activated receptor beta) (PPAR-beta) |
| Target Name | peroxisome proliferator-activated receptor delta |
| Target Type | Clinical trial target |
| Gene Age | 810 ( ENSG00000112033 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q03181 |
| Gene Card | PPARD |
| Uniprot ID | Q03181 |
| Pfam | PF00104; PF00105 |
| In ASD | no |
| Allosteric Prediction | yes (1.267656277) |
| Ortholog in Animals | Alpaca_ PPARD ( ortholog_one2one ) Dog_ PPARD ( ortholog_one2one ) GuineaPig_ PPARD ( ortholog_one2one ) Macaque_ PPARD ( ortholog_one2one ) Mouse_ Ppard ( ortholog_one2one ) Pig_ PPARD ( ortholog_one2one ) Rat_ Ppard ( ortholog_one2one ) Rabbit_ PPARD ( ortholog_one2one ) |
| Ohnologs | PPARA, RARB, PPARG |
| Paralogs | NR1H4, VDR, RARG, NR1D2, RARA, NR1H2, RORC, THRB, NR1D1, NR1H3, NR1I2, PPARG, NR1I3, RARB, RORB, PPARA, RORA, THRA |
| Tissue | NA |
| Tissue Specificity | Ubiquitous with maximal levels in placenta and skeletal muscle. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.001000(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1GWX (X-ray 2.50A ) 1Y0S (X-ray 2.65A ) 2AWH (X-ray 2.00A ) 2B50 (X-ray 2.00A ) 2BAW (X-ray 2.30A ) 2ENV (NMR - ) 2GWX (X-ray 2.30A ) 2J14 (X-ray 2.80A ) 2Q5G (X-ray 2.70A ) 2XYJ (X-ray 2.30A ) 2XYW (X-ray 3.14A ) 2XYX (X-ray 2.70A ) 2ZNP (X-ray 3.00A ) 2ZNQ (X-ray 2.65A ) 3D5F (X-ray 2.20A ) 3DY6 (X-ray 2.90A ) 3ET2 (X-ray 2.24A ) 3GWX (X-ray 2.40A ) 3GZ9 (X-ray 2.00A ) 3OZ0 (X-ray 3.00A ) 3PEQ (X-ray 2.40A ) 3SP9 (X-ray 2.30A ) 3TKM (X-ray 1.95A ) 5U3Q (X-ray 1.50A ) 5U3R (X-ray 1.95A ) 5U3S (X-ray 2.00A ) 5U3T (X-ray 1.70A ) 5U3U (X-ray 2.10A ) 5U3V (X-ray 1.84A ) 5U3W (X-ray 1.80A ) 5U3X (X-ray 2.10A ) 5U3Y (X-ray 1.90A ) 5U3Z (X-ray 1.72A ) 5U40 (X-ray 2.00A ) 5U41 (X-ray 1.90A ) 5U42 (X-ray 1.70A ) 5U43 (X-ray 1.90A ) 5U44 (X-ray 2.15A ) 5U45 (X-ray 1.95A ) 5U46 (X-ray 2.00A ) 5XMX (X-ray 2.00A ) 5Y7X (X-ray 1.70A ) 5ZXI (X-ray 2.10A ) 6A6P (X-ray 2.10A ) 7F80 (X-ray 2.80A ) 7VWE (X-ray 3.00A ) 7VWF (X-ray 1.90A ) 7VWG (X-ray 2.20A ) 7VWH (X-ray 2.10A ) 7W0G (X-ray 2.44A ) 7WGL (X-ray 2.09A ) 7WGN (X-ray 1.81A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:35675826}. |
| Mouse PG classification | NA |
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