| Gene Information | |
|---|---|
| Gene Name | PP8675 |
| Organism | Homo sapiens (Human) |
| Gene Length | 882 |
| Protein Names | Protein PML (E3 SUMO-protein ligase PML) (EC 2.3.2.-) (Promyelocytic leukemia protein) (RING finger protein 71) (RING-type E3 SUMO transferase PML) (Tripartite motif-containing protein 19) (TRIM19) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | NA |
| Evolutionary Stage | NA |
| AlphaFoldDB | P29590 |
| Gene Card | PML |
| Uniprot ID | P29590 |
| Pfam | PF12126; PF00643 |
| In ASD | no |
| Allosteric Prediction | NA |
| Ortholog in Animals | NA |
| Ohnologs | NA |
| Paralogs | NA |
| Tissue | NA |
| Tissue Specificity | NA |
| Pharmacological Animal Models | 0.004925(Chimpanzee);0.009983(Mouse);NULL(Rat);0.024615(Rabbit) |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
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| Gene Ontology (molecular function) |
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| PDB | 1BOR (NMR - ) 2MVW (NMR - ) 2MWX (NMR - ) 4WJN (X-ray 1.50A ) 4WJO (X-ray 1.46A ) 5YUF (X-ray 1.60A ) 6IMQ (X-ray 2.06A ) 6UYO (X-ray 1.64A ) 6UYP (X-ray 1.42A ) 6UYQ (X-ray 1.50A ) 6UYR (X-ray 1.30A ) 6UYS (X-ray 1.59A ) 6UYT (X-ray 1.66A ) 6UYU (X-ray 1.66A ) 6UYV (X-ray 1.40A ) 8DJI (X-ray 1.97A ) |
| DBSNP | rs5742915 |
| Subcellular location [CC] | Nucleus. Nucleus, nucleoplasm. Cytoplasm {ECO:0000269|PubMed:27211601}. Nucleus, PML body {ECO:0000269|PubMed:20501696, ECO:0000269|PubMed:27211601}. Nucleus, nucleolus. Endoplasmic reticulum membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Isoform PML-1 can shuttle between the nucleus and cytoplasm. Isoform PML-2, isoform PML-3, isoform PML-4, isoform PML-5 and isoform PML-6 are nuclear isoforms whereas isoform PML-7 and isoform PML-14 lacking the nuclear localization signal are cytoplasmic isoforms. Detected in the nucleolus after DNA damage. Acetylation at Lys-487 is essential for its nuclear localization. Within the nucleus, most of PML is expressed in the diffuse nuclear fraction of the nucleoplasm and only a small fraction is found in the matrix-associated nuclear bodies (PML-NBs). The transfer of PML from the nucleoplasm to PML-NBs depends on its phosphorylation and sumoylation. The B1 box and the RING finger are also required for the localization in PML-NBs. Also found in specific membrane structures termed mitochondria-associated membranes (MAMs) which connect the endoplasmic reticulum (ER) and the mitochondria. Sequestered in the cytoplasm by interaction with rabies virus phosphoprotein. |
| Mouse PG classification | NA |
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