Gene Information
Gene NameTGM2
OrganismHomo sapiens (Human)
Gene Length687
Protein NamesProtein-glutamine gamma-glutamyltransferase 2 (EC 2.3.2.13) (Erythrocyte transglutaminase) (Heart G alpha(h)) (hhG alpha(h)) (Isopeptidase TGM2) (EC 3.4.-.-) (Protein G alpha(h)) (G(h)) (Protein-glutamine deamidase TGM2) (EC 3.5.1.44) (Protein-glutamine dopaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine histaminyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine noradrenalinyltransferase TGM2) (EC 2.3.1.-) (Protein-glutamine serotonyltransferase TGM2) (EC 2.3.1.-) (Tissue transglutaminase) (tTG) (tTgase) (Transglutaminase C) (TG(C)) (TGC) (TGase C) (Transglutaminase H) (TGase H) (Transglutaminase II) (TGase II) (Transglutaminase-2) (TG2) (TGase-2) (hTG2)
Target Nameprotein-glutamine gamma-glutamyltransferase 2
Target TypeNA
Gene Age454 ( ENSG00000198959 )
Evolutionary StageEumetazoa
AlphaFoldDBP21980
Gene CardTGM2
Uniprot IDP21980
PfamPF00927; PF01841; PF00868
In ASDyes
Allosteric Predictionyes (1.653261255)
Ortholog in AnimalsAlpaca_ TGM2 ( ortholog_one2one )
Dog_ TGM2 ( ortholog_one2one )
GuineaPig_ TGM2 ( ortholog_one2one )
Macaque_ TGM2 ( ortholog_one2one )
Mouse_ Tgm2 ( ortholog_one2one )
Pig_ TGM2 ( ortholog_one2one )
Rat_ Tgm2 ( ortholog_one2one )
Rabbit_ TGM2 ( ortholog_one2one )
OhnologsTGM5, TGM7, EPB42
ParalogsEPB42, TGM6, TGM3, TGM5, TGM7, TGM4, TGM1, F13A1
TissueNA
Tissue SpecificityNA
Pharmacological Animal ModelsNA
Gene Ontology
(biological process)
Gene Ontology
(cellular component)
Gene Ontology
(molecular function)
PDB 1KV3  (X-ray  2.80A  )  2Q3Z  (X-ray  2.00A  )  3LY6  (X-ray  3.14A  )  3S3J  (X-ray  2.25A  )  3S3P  (X-ray  2.50A  )  3S3S  (X-ray  2.30A  )  4PYG  (X-ray  2.80A  )  6A8P  (X-ray  2.54A  )  6KZB  (X-ray  3.35A  ) 
DBSNP rs41274720  rs45530133  rs45567334  rs141603506  rs45629036  rs45556333 
Subcellular location [CC]Cytoplasm, cytosol {ECO:0000269|PubMed:24349085, ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:9575137}. Nucleus {ECO:0000269|PubMed:29618516, ECO:0000269|PubMed:9575137}. Chromosome {ECO:0000269|PubMed:9575137}. Secreted, extracellular space, extracellular matrix {ECO:0000269|PubMed:12506096, ECO:0000269|PubMed:1683874}. Cell membrane {ECO:0000250|UniProtKB:Q9WVJ6}. Mitochondrion {ECO:0000269|PubMed:24349085}. Note=Mainly localizes to the cytosol (PubMed:9575137). Present at much lower level in the nucleus and chromatin (PubMed:9575137). Also secreted via a non-classical secretion pathway to the extracellular matrix (PubMed:27270573). {ECO:0000269|PubMed:9575137, ECO:0000303|PubMed:27270573}.;
[Isoform 2]: Cytoplasm, perinuclear region {ECO:0000269|PubMed:17116873}.
Mouse PG classificationNA
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