| Gene Information | |
|---|---|
| Gene Name | ELAVL4 |
| Organism | Homo sapiens (Human) |
| Gene Length | 385 |
| Protein Names | ELAV-like protein 4 (Hu-antigen D) (HuD) (Paraneoplastic encephalomyelitis antigen HuD) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | >4290 ( ENSG00000162374 ) |
| Evolutionary Stage | Eukaryota |
| AlphaFoldDB | P26378 |
| Gene Card | ELAVL4 |
| Uniprot ID | P26378 |
| Pfam | PF00076 |
| In ASD | no |
| Allosteric Prediction | no (-0.917128206) |
| Ortholog in Animals | Alpaca_ ELAVL4 ( ortholog_one2one ) Dog_ ELAVL4 ( ortholog_one2one ) Macaque_ ELAVL4 ( ortholog_one2one ) Mouse_ Elavl4 ( ortholog_one2one ) Pig_ ELAVL4 ( ortholog_one2one ) Rat_ Elavl4 ( ortholog_one2one ) Rabbit_ ELAVL4 ( ortholog_one2one ) |
| Ohnologs | ELAVL1, ELAVL3 |
| Paralogs | RBMS2, PABPC1, PABPC3, RBM24, ELAVL3, RBMS1, ELAVL2, PUF60, RBM34, RBM45, HNRNPR, SYNCRIP, PABPC1L, PABPC5, RBM14, PABPC1L2A, PABPC1L2B, SF3B4, RBM38, ELAVL1, TARDBP, RBMS3, PABPC4, PABPC4L |
| Tissue | brain, cerebral.cortex |
| Tissue Specificity | Expressed in pancreatic beta cells (at protein level) (PubMed:22387028). Expressed in the brain (PubMed:1655278, PubMed:14702039). {ECO:0000269|PubMed:14702039, ECO:0000269|PubMed:1655278, ECO:0000269|PubMed:22387028}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 1FXL (X-ray 1.80A ) 1G2E (X-ray 2.30A ) |
| DBSNP | rs17853533 rs2494876 rs17853531 |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21088113}. Perikaryon {ECO:0000250|UniProtKB:O09032}. Cell projection, dendrite {ECO:0000250|UniProtKB:O09032}. Cell projection, axon {ECO:0000250|UniProtKB:Q61701}. Cell projection, growth cone {ECO:0000250|UniProtKB:Q61701}. Note=Co-localizes with ribosomal RNA in polysomes. {ECO:0000250|UniProtKB:O09032}. |
| Mouse PG classification | NA |
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