| Gene Information | |
|---|---|
| Gene Name | AIM2 |
| Organism | Homo sapiens (Human) |
| Gene Length | 343 |
| Protein Names | Interferon-inducible protein AIM2 (Absent in melanoma 2) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 168 ( ENSG00000163568 ) |
| Evolutionary Stage | Mammalia |
| AlphaFoldDB | O14862 |
| Gene Card | AIM2 |
| Uniprot ID | O14862 |
| Pfam | PF02760; PF02758 |
| In ASD | no |
| Allosteric Prediction | no (-0.415355251) |
| Ortholog in Animals | Alpaca_ AIM2 ( ortholog_one2one ) Macaque_ AIM2 ( ortholog_one2one ) Mouse_ Aim2 ( ortholog_one2one ) Rat_ Aim2 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | IFI16, MNDA, PYHIN1 |
| Tissue | lymph.node, appendix, spleen, tonsil |
| Tissue Specificity | Expressed in spleen, small intestine, peripheral blood leukocytes, and testis. {ECO:0000269|PubMed:9242382}. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.004323(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3RN2 (X-ray 2.55A ) 3RN5 (X-ray 2.50A ) 3VD8 (X-ray 2.07A ) 4O7Q (X-ray 1.82A ) 6MB2 (EM 5.00A ) 7K3R (EM 3.20A ) |
| DBSNP | rs2276405 rs778047649 |
| Subcellular location [CC] | Nucleus. Cytoplasm. Note=Activated inflammasomes can aggregate in the cytosol as speck-like particles. |
| Mouse PG classification | NA |
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