| Gene Information | |
|---|---|
| Gene Name | HDAC1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 482 |
| Protein Names | Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-) |
| Target Name | histone deacetylase 1 |
| Target Type | Successful target |
| Gene Age | 680 ( ENSG00000116478 ) |
| Evolutionary Stage | Cellular_organisms |
| AlphaFoldDB | Q13547 |
| Gene Card | HDAC1 |
| Uniprot ID | Q13547 |
| Pfam | PF00850 |
| In ASD | yes |
| Allosteric Prediction | yes (1.126300577) |
| Ortholog in Animals | Alpaca_ HDAC1 ( ortholog_one2one ) Dog_ HDAC1 ( ortholog_one2one ) GuineaPig_ HDAC1 ( ortholog_one2one ) Macaque_ HDAC1 ( ortholog_one2one ) Mouse_ Hdac1 ( ortholog_one2one ) Pig_ HDAC1 ( ortholog_one2one ) Rat_ Hdac1l ( ortholog_one2one ) Rabbit_ HDAC1 ( ortholog_one2one ) |
| Ohnologs | HDAC2 |
| Paralogs | HDAC4, HDAC11, HDAC8, HDAC3, HDAC7, HDAC6, HDAC10, HDAC2, HDAC5, HDAC9 |
| Tissue | NA |
| Tissue Specificity | Ubiquitous, with higher levels in heart, pancreas and testis, and lower levels in kidney and brain. |
| Pharmacological Animal Models | NULL(Chimpanzee);NULL(Mouse);0.222430(Rat);NULL(Rabbit) |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 4BKX (X-ray 3.00A ) 5ICN (X-ray 3.30A ) 6Z2J (EM 4.00A ) 6Z2K (EM 4.50A ) 7AO8 (EM 4.50A ) 7AO9 (EM 6.10A ) 7AOA (EM 19.40A ) 7SME (X-ray 2.64A ) |
| DBSNP | NA |
| Subcellular location [CC] | Nucleus {ECO:0000269|PubMed:10846170}. |
| Mouse PG classification | NA |
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