| Gene Information | |
|---|---|
| Gene Name | TMEM100 |
| Organism | Homo sapiens (Human) |
| Gene Length | 134 |
| Protein Names | Transmembrane protein 100 |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 544 ( ENSG00000166292 ) |
| Evolutionary Stage | Vertebrata |
| AlphaFoldDB | Q9NV29 |
| Gene Card | TMEM100 |
| Uniprot ID | Q9NV29 |
| Pfam | PF16311 |
| In ASD | no |
| Allosteric Prediction | no (-1.33725478) |
| Ortholog in Animals | Alpaca_ TMEM100 ( ortholog_one2one ) Dog_ TMEM100 ( ortholog_one2one ) GuineaPig_ TMEM100 ( ortholog_one2one ) Macaque_ TMEM100 ( ortholog_one2one ) Mouse_ Tmem100 ( ortholog_one2one ) Pig_ TMEM100 ( ortholog_one2one ) Rat_ Tmem100 ( ortholog_one2one ) Rabbit_ TMEM100 ( ortholog_one2one ) |
| Ohnologs | NA |
| Paralogs | PIRT |
| Tissue | lung |
| Tissue Specificity | Expressed in neurons of the myenteric and submucosal plexuses in the gastric body, jejunum and proximal colon. Expressed in arterial endothelial cells and neurons of the central nervous system and peripheral nervous system. Expressed in umbilical artery endothelial cells (at protein level). {ECO:0000269|PubMed:22783020, ECO:0000269|PubMed:23485812}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cell membrane; Multi-pass membrane protein. Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. Perikaryon. Cytoplasm, perinuclear region. Endoplasmic reticulum. Note=Colocalized with HSPA5 in the endoplasmic reticulum (ER). Enriched in ER microsome. Colocalized with BMP4 in neural cell bodies and neural fibers of the enteric nervous system. |
| Mouse PG classification | NA |
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