| Gene Information | |
|---|---|
| Gene Name | AFAP1L1 |
| Organism | Homo sapiens (Human) |
| Gene Length | 768 |
| Protein Names | Actin filament-associated protein 1-like 1 (AFAP1-like protein 1) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 680 ( ENSG00000157510 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | Q8TED9 |
| Gene Card | AFAP1L1 |
| Uniprot ID | Q8TED9 |
| Pfam | PF00169 |
| In ASD | no |
| Allosteric Prediction | no (-1.495780395) |
| Ortholog in Animals | Alpaca_ AFAP1L1 ( ortholog_one2one ) Dog_ AFAP1L1 ( ortholog_one2one ) GuineaPig_ AFAP1L1 ( ortholog_one2one ) Macaque_ AFAP1L1 ( ortholog_one2one ) Mouse_ Afap1l1 ( ortholog_one2one ) Pig_ AFAP1L1 ( ortholog_one2one ) Rat_ Afap1l1 ( ortholog_one2one ) Rabbit_ AFAP1L1 ( ortholog_one2one ) |
| Ohnologs | AFAP1L2, AFAP1 |
| Paralogs | AFAP1L2, AFAP1 |
| Tissue | NA |
| Tissue Specificity | Expressed in breast, colon and brain. In all 3 tissues, expressed in the microvasculature (at protein level). In addition, in the breast, found in the contractile myoepithelial cell layer which surrounds the breast ducts (at protein level). In the colon, expressed in the mucous membrane and colonic crypts and in the smooth muscle cell layer which provide movement of the colon (at protein level). In the cerebellum, localized around the Purkinje neurons and the granule cells of the granular layer, but not inside cell bodies (at protein level). Outside of the cerebellar cortex, expressed in glial cells (at protein level). Highly expressed away from the cell bodies within the dentate nucleus (at protein level). {ECO:0000269|PubMed:21333378}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
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| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
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| PDB | NA |
| DBSNP | NA |
| Subcellular location [CC] | Cytoplasm {ECO:0000269|PubMed:21333378}. Cell projection, podosome {ECO:0000269|PubMed:21333378}. Cell projection, invadopodium {ECO:0000269|PubMed:21333378}. Cytoplasm, cytoskeleton, stress fiber {ECO:0000269|PubMed:21333378}. |
| Mouse PG classification | NA |
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