| Gene Information | |
|---|---|
| Gene Name | ARHGAP32 |
| Organism | Homo sapiens (Human) |
| Gene Length | 2087 |
| Protein Names | Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP) |
| Target Name | NA |
| Target Type | NA |
| Gene Age | 950 ( ENSG00000134909 ) |
| Evolutionary Stage | Eumetazoa |
| AlphaFoldDB | A7KAX9 |
| Gene Card | ARHGAP32 |
| Uniprot ID | A7KAX9 |
| Pfam | PF00620; PF14604 |
| In ASD | no |
| Allosteric Prediction | no (-0.195729301) |
| Ortholog in Animals | Alpaca_ ARHGAP32 ( ortholog_one2one ) Dog_ ARHGAP32 ( ortholog_one2one ) GuineaPig_ ARHGAP32 ( ortholog_one2one ) Macaque_ ARHGAP32 ( ortholog_one2one ) Mouse_ Arhgap32 ( ortholog_one2one ) Pig_ ARHGAP32 ( ortholog_one2one ) Rat_ Arhgap32 ( ortholog_one2one ) Rabbit_ ARHGAP32 ( ortholog_one2one ) |
| Ohnologs | ARHGAP31 |
| Paralogs | ARHGAP30, ARHGAP31, ARHGAP33 |
| Tissue | NA |
| Tissue Specificity | Isoform 1 and isoform 2 are highly expressed in brain and testis. Isoform 1 is also expressed in other tissues such as lung, liver and spleen. {ECO:0000269|PubMed:12446789}. |
| Pharmacological Animal Models | NA |
| Gene Ontology (biological process) |
|
| Gene Ontology (cellular component) |
|
| Gene Ontology (molecular function) |
|
| PDB | 3IUG (X-ray 1.77A ) |
| DBSNP | NA |
| Subcellular location [CC] | Postsynaptic density {ECO:0000250|UniProtKB:Q811P8}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q811P8}. Cytoplasm, cell cortex {ECO:0000269|PubMed:12446789}. Endosome membrane {ECO:0000269|PubMed:17663722}. Golgi apparatus membrane {ECO:0000269|PubMed:17663722}. Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q811P8}. Membrane {ECO:0000269|PubMed:17663722}. Note=Association to membrane via PX domain (PubMed:17663722). Associated with cortical actin in undifferentiated neuroblastoma cells, but localized to dendritic spine and postsynaptic density after differentiation (By similarity). Colocalizes with EGFR at the cell membrane upon EGF treatment (PubMed:12446789). Colocalizes with GAB2 at the cell membrane (PubMed:12819203). {ECO:0000250|UniProtKB:Q811P8, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:17663722}. |
| Mouse PG classification | NA |
| click here to return to the previous page | |